The endophytic fungus Trametes hirsuta as a novel alternative source of podophyllotoxin and related aryl tetralin lignans - PubMed (original) (raw)

. 2006 Apr 20;122(4):494-510.

doi: 10.1016/j.jbiotec.2005.10.015. Epub 2005 Dec 20.

Asiya Nazir, Raman Chawla, Rajesh Arora, S Riyaz-Ul-Hasan, Touseef Amna, Bilal Ahmed, Vijeshwar Verma, Shikha Singh, Ravinder Sagar, Ashok Sharma, Raj Kumar, Rakesh Kumar Sharma, Ghulam Nabi Qazi

Affiliations

Satish Chandra Puri et al. J Biotechnol. 2006.

Abstract

The aryl tetralin lignans are synthesized by Podophyllum sps. and are in great demand worldwide due to their use in synthesis of topoisomerase inhibitors. However, the sustained production of these aryl tetralin lignans requires large-scale harvesting from the natural environments, which has resulted in the plant-endangered status. In view of the difficulties in their total chemical synthesis, cultivation and failure of metabolic engineering approaches, there is a need to search for alternative sources of production of aryl tetralin lignans. We unequivocally established the methodology for isolation, identification, and characterization of a novel fungal endophyte (Trametes hirsuta) that produces aryl tetralin lignans consistently as shown by HPLC, LC-MS, LC/MS-MS and (1)H NMR. The lignans produced by the microorganism are biologically active, and exhibit potent antioxidant, anticancer and radioprotective properties. This strategy promises to improve the production of these therapeutically important compounds at lower costs.

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