An endophytic fungus from Nothapodytes foetida that produces camptothecin - PubMed (original) (raw)
. 2005 Dec;68(12):1717-9.
doi: 10.1021/np0502802.
Affiliations
- PMID: 16378360
- DOI: 10.1021/np0502802
An endophytic fungus from Nothapodytes foetida that produces camptothecin
Satish Chander Puri et al. J Nat Prod. 2005 Dec.
Abstract
A fungal endophytic isolate, camptothecin, has been isolated from the inner bark of the plant Nothapodytes foetidafrom the Western coast of India. The fungus, which belongs to the family Phycomycetes, produced the anticancer drug lead compound camptothecin (1) when grown in a synthetic liquid medium (Sabouraud broth) under shake flask and bench scale fermentation conditions. Compound 1 was identified by means of chromatographic and spectroscopic methods. It was also compared with an authentic example for its biological activity against a number of human cancer cell lines. Isolation of an organism producing 1 and its fermentation may, in the future, provide an easily accessible source for the production of this anticancer drug precursor molecule.
Similar articles
- An endophytic Neurospora sp. from Nothapodytes foetida producing camptothecin.
Rehman S, Shawl AS, Verma V, Kour A, Athar M, Andrabi R, Sultan P, Qazi GN. Rehman S, et al. Prikl Biokhim Mikrobiol. 2008 Mar-Apr;44(2):225-31. Prikl Biokhim Mikrobiol. 2008. PMID: 18669267 - Bioreactor studies on the endophytic fungus Entrophospora infrequens for the production of an anticancer alkaloid camptothecin.
Amna T, Puri SC, Verma V, Sharma JP, Khajuria RK, Musarrat J, Spiteller M, Qazi GN. Amna T, et al. Can J Microbiol. 2006 Mar;52(3):189-96. doi: 10.1139/w05-122. Can J Microbiol. 2006. PMID: 16604115 - An endophytic fungus from Camptotheca acuminata that produces camptothecin and analogues.
Kusari S, Zühlke S, Spiteller M. Kusari S, et al. J Nat Prod. 2009 Jan;72(1):2-7. doi: 10.1021/np800455b. J Nat Prod. 2009. PMID: 19119919 - Camptothecin: therapeutic potential and biotechnology.
Sirikantaramas S, Asano T, Sudo H, Yamazaki M, Saito K. Sirikantaramas S, et al. Curr Pharm Biotechnol. 2007 Aug;8(4):196-202. doi: 10.2174/138920107781387447. Curr Pharm Biotechnol. 2007. PMID: 17691988 Review. - Camptothecin, over four decades of surprising findings.
Lorence A, Nessler CL. Lorence A, et al. Phytochemistry. 2004 Oct;65(20):2735-49. doi: 10.1016/j.phytochem.2004.09.001. Phytochemistry. 2004. PMID: 15474560 Review.
Cited by
- Evaluation of the potential of endophytic Trichoderma sp. isolated from medicinal plant Ampelopsis japonica against MRSA and bioassay-guided separation of the anti-MRSA compound.
Li J, Xie S, Gao Q, Deng Z. Li J, et al. Braz J Microbiol. 2024 Mar;55(1):543-556. doi: 10.1007/s42770-024-01250-z. Epub 2024 Jan 23. Braz J Microbiol. 2024. PMID: 38261262 Free PMC article. - Cannabis Microbiome and the Role of Endophytes in Modulating the Production of Secondary Metabolites: An Overview.
Taghinasab M, Jabaji S. Taghinasab M, et al. Microorganisms. 2020 Mar 2;8(3):355. doi: 10.3390/microorganisms8030355. Microorganisms. 2020. PMID: 32131457 Free PMC article. Review. - Endophytic bacteria: a new source of bioactive compounds.
Singh M, Kumar A, Singh R, Pandey KD. Singh M, et al. 3 Biotech. 2017 Oct;7(5):315. doi: 10.1007/s13205-017-0942-z. Epub 2017 Sep 14. 3 Biotech. 2017. PMID: 28955612 Free PMC article. Review. - Bioprocessing of camptothecin from Alternaria brassicicola, an endophyte of Catharanthus roseus, with a strong antiproliferative activity and inhibition to Topoisomerases.
El-Hady NAAA, ElSayed AI, Wadan KM, El-Saadany SS, El-Sayed ASA. El-Hady NAAA, et al. Microb Cell Fact. 2024 Jul 26;23(1):214. doi: 10.1186/s12934-024-02471-5. Microb Cell Fact. 2024. PMID: 39060918 Free PMC article. - Phylogenetic and chemical diversity of fungal endophytes isolated from Silybum marianum (L) Gaertn. (milk thistle).
Raja HA, Kaur A, El-Elimat T, Figueroa M, Kumar R, Deep G, Agarwal R, Faeth SH, Cech NB, Oberlies NH. Raja HA, et al. Mycology. 2015 Jan 2;6(1):8-27. doi: 10.1080/21501203.2015.1009186. Epub 2015 Feb 23. Mycology. 2015. PMID: 26000195 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources