Polymeric nanoparticulate delivery system for Indocyanine green: biodistribution in healthy mice - PubMed (original) (raw)
Comparative Study
. 2006 Feb 3;308(1-2):200-4.
doi: 10.1016/j.ijpharm.2005.11.003.
Affiliations
- PMID: 16386861
- DOI: 10.1016/j.ijpharm.2005.11.003
Comparative Study
Polymeric nanoparticulate delivery system for Indocyanine green: biodistribution in healthy mice
Vishal Saxena et al. Int J Pharm. 2006.
Abstract
The objective of this study is to investigate the biodistribution of Indocyanine green (ICG) in healthy mice, when delivered through polymeric nanoparticles. The poly(DL-lactic-co-glycolic acid) (PLGA) nanoparticles entrapping ICG were engineered and characterized. The extraction method for ICG recovery from biological samples was developed. The biodistribution of ICG was determined in healthy C57BL/6 mice (female, 10-week old) when delivered through PLGA nanoparticles in comparison to free ICG solution, using a fluorometric assay method. The extraction method for ICG shows efficiency above 80% for various organs and plasma. When nanoparticles were used to deliver ICG, 2-8 times higher concentrations of ICG was deposited in various organs, with 5-10 times higher plasma levels till 4 h, after an i.v. dose as compared to free ICG solution. In conclusion, the nanoparticle formulation significantly increased the ICG concentration and circulation time in plasma as well as the ICG uptake, accumulation and retention in various organs. Overall, this study represents the first step in exploring and establishing the potential of nanoparticles as an ICG-delivery system for use in tumor-diagnosis and photodynamic therapy.
Similar articles
- Indocyanine green-loaded biodegradable nanoparticles: preparation, physicochemical characterization and in vitro release.
Saxena V, Sadoqi M, Shao J. Saxena V, et al. Int J Pharm. 2004 Jul 8;278(2):293-301. doi: 10.1016/j.ijpharm.2004.03.032. Int J Pharm. 2004. PMID: 15196634 - Biodistribution of indocyanine green-loaded nanoparticles with surface modifications of PEG and folic acid.
Ma Y, Sadoqi M, Shao J. Ma Y, et al. Int J Pharm. 2012 Oct 15;436(1-2):25-31. doi: 10.1016/j.ijpharm.2012.06.007. Epub 2012 Jun 9. Int J Pharm. 2012. PMID: 22692077 - Indocyanine green nanoparticles useful for photomedicine.
Gomes AJ, Lunardi LO, Marchetti JM, Lunardi CN, Tedesco AC. Gomes AJ, et al. Photomed Laser Surg. 2006 Aug;24(4):514-21. doi: 10.1089/pho.2006.24.514. Photomed Laser Surg. 2006. PMID: 16942434 - Preparation and characterization of a polymeric (PLGA) nanoparticulate drug delivery system with simultaneous incorporation of chemotherapeutic and thermo-optical agents.
Manchanda R, Fernandez-Fernandez A, Nagesetti A, McGoron AJ. Manchanda R, et al. Colloids Surf B Biointerfaces. 2010 Jan 1;75(1):260-7. doi: 10.1016/j.colsurfb.2009.08.043. Epub 2009 Sep 4. Colloids Surf B Biointerfaces. 2010. PMID: 19775872 - Hepatic elimination of indocyanine green with special reference to distribution kinetics and the influence of plasma protein binding.
Ott P. Ott P. Pharmacol Toxicol. 1998;83 Suppl 2:1-48. doi: 10.1111/j.1600-0773.1998.tb01945.x. Pharmacol Toxicol. 1998. PMID: 9695126 Review. No abstract available.
Cited by
- Development of a cationic polyethyleneimine-poly(lactic-_co_-glycolic acid) nanoparticle system for enhanced intracellular delivery of biologics.
Tracey SR, Smyth P, Herron UM, Burrows JF, Porter AJ, Barelle CJ, Scott CJ. Tracey SR, et al. RSC Adv. 2023 Nov 17;13(48):33721-33735. doi: 10.1039/d3ra06050k. eCollection 2023 Nov 16. RSC Adv. 2023. PMID: 38020041 Free PMC article. - Quatramer™ encapsulation of dual-targeted PI3-Kδ/HDAC6 inhibitor, HSB-510, suppresses growth of breast cancer.
Tiwari S, Liu S, Anees M, Mehrotra N, Thakur A, Tawa GJ, Grewal G, Stone R, Kharbanda S, Singh H. Tiwari S, et al. Bioeng Transl Med. 2023 May 12;8(5):e10541. doi: 10.1002/btm2.10541. eCollection 2023 Sep. Bioeng Transl Med. 2023. PMID: 37693068 Free PMC article. - In-vivo time course of organ uptake and blood-brain-barrier permeation of poly(L-lactide) and poly(perfluorodecyl acrylate) nanoparticles with different surface properties in unharmed and brain-traumatized rats.
Bechinger P, Serrano Sponton L, Grützner V, Musyanovych A, Jussen D, Krenzlin H, Eldahaby D, Riede N, Kempski O, Ringel F, Alessandri B. Bechinger P, et al. Front Neurol. 2023 Feb 6;14:994877. doi: 10.3389/fneur.2023.994877. eCollection 2023. Front Neurol. 2023. PMID: 36814997 Free PMC article. - Protease-activated indocyanine green nanoprobes for intraoperative NIR fluorescence imaging of primary tumors.
Lew B, George M, Blair S, Zhu Z, Liang Z, Ludwig J, Kim CY, Kim KK, Gruev V, Choi H. Lew B, et al. Nanoscale Adv. 2022 Jul 1;4(19):4041-4050. doi: 10.1039/d2na00276k. eCollection 2022 Sep 27. Nanoscale Adv. 2022. PMID: 36285222 Free PMC article. - Indocyanine Green-Loaded PLGA Nanoparticles Conjugated with Hyaluronic Acid Improve Target Specificity in Cervical Cancer Tumors.
Choi S, Lee SH, Park S, Park SH, Park C, Key J. Choi S, et al. Yonsei Med J. 2021 Nov;62(11):1042-1051. doi: 10.3349/ymj.2021.62.11.1042. Yonsei Med J. 2021. PMID: 34672138 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources