Interactions between carnosine and captopril on free radical scavenging activity and angiotensin-converting enzyme activity in vitro - PubMed (original) (raw)
Interactions between carnosine and captopril on free radical scavenging activity and angiotensin-converting enzyme activity in vitro
Kazuo Nakagawa et al. Yakugaku Zasshi. 2006 Jan.
Free article
Abstract
Interactions between carnosine (beta-alanyl-L-histidine), being plentiful in skeletal muscles and neuronal tissues, and captopril, a widely used angiotensin-converting enzyme (ACE) inhibitor, were examined concerning free radical scavenging activity and ACE activity in vitro. Not only captopril, but also carnosine, at concentrations less than those ordinarily found in muscles and neuronal tissues, significantly scavenged 2,2'-azinobis (3-ethylbenzothiazoline-6-sulphonate) (ABTS) radical cations, and inhibited ACE activity. Cupric ions reversed the ABTS scavenging activity of carnosine and captopril, whereas cupric ions strengthened the inhibitory action of carnosine on ACE activity. In contrast, cupric ions antagonized the inhibition of ACE activity induced by ethylenediaminetetraacetic acid, indicating that the inhibitory effect of carnosine on ACE activity is not related to the chelating action of carnosine. On the other hand, carnosine and captopril synergistically enhanced the free radical scavenging activity, but not the inhibitory effect on the ACE activity. These data suggest that carnosine in its concurrent use with captopril could act as a beneficial free radical scavenger, with less danger of overdose, in the inhibition of ACE activity.
Similar articles
- Free radical scavenging: a potentially beneficial action of thiol-containing angiotensin converting enzyme inhibitors.
Chopra M, McMurray J, Stewart J, Dargie HJ, Smith WE. Chopra M, et al. Biochem Soc Trans. 1990 Dec;18(6):1184-5. doi: 10.1042/bst0181184. Biochem Soc Trans. 1990. PMID: 2088853 - Free radical scavenging properties of alacepril metabolites and lisinopril.
Noda Y, Mori A, Packer L. Noda Y, et al. Res Commun Mol Pathol Pharmacol. 1997 May;96(2):125-36. Res Commun Mol Pathol Pharmacol. 1997. PMID: 9226747 - Sulfhydryl group in angiotensin converting enzyme inhibitors and superoxide radical formation.
Mehta JL, Nicolini FA, Lawson DL. Mehta JL, et al. J Cardiovasc Pharmacol. 1990 Nov;16(5):847-9. doi: 10.1097/00005344-199011000-00023. J Cardiovasc Pharmacol. 1990. PMID: 1703610 - Angiotensin-converting enzyme inhibitors in hypertension: a review.
Salvetti A, Pedrinelli R, Arzilli F, Abdel-Haq B, Magagna A, Lucarini A, Graziadei L, Nuccorini A, Taddei S. Salvetti A, et al. Int J Clin Pharmacol Res. 1985;5(6):429-38. Int J Clin Pharmacol Res. 1985. PMID: 3005182 Review. - [Carnosine, carnosinase and kidney diseases].
Kiliś-Pstrusińska K. Kiliś-Pstrusińska K. Postepy Hig Med Dosw (Online). 2012 Apr 20;66:215-21. doi: 10.5604/17322693.991600. Postepy Hig Med Dosw (Online). 2012. PMID: 22706107 Review. Polish.
Cited by
- Hydrogen Sulfide and Carnosine: Modulation of Oxidative Stress and Inflammation in Kidney and Brain Axis.
Calabrese V, Scuto M, Salinaro AT, Dionisio G, Modafferi S, Ontario ML, Greco V, Sciuto S, Schmitt CP, Calabrese EJ, Peters V. Calabrese V, et al. Antioxidants (Basel). 2020 Dec 18;9(12):1303. doi: 10.3390/antiox9121303. Antioxidants (Basel). 2020. PMID: 33353117 Free PMC article. Review. - Muscle carnosine metabolism and beta-alanine supplementation in relation to exercise and training.
Derave W, Everaert I, Beeckman S, Baguet A. Derave W, et al. Sports Med. 2010 Mar 1;40(3):247-63. doi: 10.2165/11530310-000000000-00000. Sports Med. 2010. PMID: 20199122 Review. - Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift.
Peters V, Schmitt CP, Weigand T, Klingbeil K, Thiel C, van den Berg A, Calabrese V, Nawroth P, Fleming T, Forsberg E, Wagner AH, Hecker M, Vistoli G. Peters V, et al. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1102-1110. doi: 10.1080/14756366.2017.1355793. J Enzyme Inhib Med Chem. 2017. PMID: 28776438 Free PMC article. - Anserine and Carnosine Induce HSP70-Dependent H2S Formation in Endothelial Cells and Murine Kidney.
Wetzel C, Pfeffer T, Bulkescher R, Zemva J, Modafferi S, Polimeni A, Salinaro AT, Calabrese V, Schmitt CP, Peters V. Wetzel C, et al. Antioxidants (Basel). 2022 Dec 28;12(1):66. doi: 10.3390/antiox12010066. Antioxidants (Basel). 2022. PMID: 36670928 Free PMC article. - Carnosine Activates Cellular Stress Response in Podocytes and Reduces Glycative and Lipoperoxidative Stress.
Scuto M, Trovato Salinaro A, Modafferi S, Polimeni A, Pfeffer T, Weigand T, Calabrese V, Schmitt CP, Peters V. Scuto M, et al. Biomedicines. 2020 Jun 26;8(6):177. doi: 10.3390/biomedicines8060177. Biomedicines. 2020. PMID: 32604897 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous