Seroepidemiology of strongyloidiasis in the Peruvian Amazon - PubMed (original) (raw)

Margaret Kosek, Robert H Gilman, Julianna Cordova, Caryn Bern, Cesar Banda Chavez, Maribel Paredes Olortegui, Carmen Montalvan, Graciela Meza Sanchez, Bevelle Worthen, James Worthen, Fay Leung, Carlos Vidal Oré

Affiliations

PMID: 16407351
PMCID: PMC1483914

Seroepidemiology of strongyloidiasis in the Peruvian Amazon

Pablo P Yori et al. Am J Trop Med Hyg. 2006 Jan.

Abstract

A stool and serosurvey for Strongyloides stercoralis was conducted in a community in the Peruvian Amazon region. Strongyloidiasis stercoralis was identified in the stool of 69 (8.7%) of 792 participants. Six hundred nine sera were tested using by an enzyme-linked immunosorbent assay (ELISA), which had a sensitivity of 92% and a specificity of 94%; 442 (72%) were positive. In multivariable logistic regression models, having S. stercoralis in stool was associated with hookworm in the same specimen (odds ratio [OR] = 4.44, 95% confidence interval [CI] = 2.02-9.79), occasionally or never wearing shoes (OR = 1.89, 95% CI = 1.10-3.27), and increasing age (OR = 1.012 for each one-year increase, 95% CI = 1.00-1.03). Similarly, occasionally or never wearing shoes (OR = 1.54, 95% CI = 1.01-2.37) and increasing age (OR = 1.04 for each one-year increase, 95% CI = 1.02-1.06) were associated with an increased risk of a positive S. stercoralis ELISA result. The ELISA had a negative predictive value of 98% and is an excellent screening test for strongyloidiasis.

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Figures

FIGURE 1

Study site in the Peruvian Amazon.

FIGURE 2

Age-specific prevalence of Strongyloides stercoralis by stool examination and serologic results. ELISA= enzyme-linked immunosorbent assay.

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Seroepidemiology of strongyloidiasis in the Peruvian Amazon - PubMed (original) (raw)