Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits - PubMed (original) (raw)
. 2006 Jan 13;311(5758):233-5.
doi: 10.1126/science.1121325.
Affiliations
- PMID: 16410524
- DOI: 10.1126/science.1121325
Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits
János Szabadics et al. Science. 2006.
Abstract
Axons in the cerebral cortex receive synaptic input at the axon initial segment almost exclusively from gamma-aminobutyric acid-releasing (GABAergic) axo-axonic cells (AACs). The axon has the lowest threshold for action potential generation in neurons; thus, AACs are considered to be strategically placed inhibitory neurons controlling neuronal output. However, we found that AACs can depolarize pyramidal cells and can initiate stereotyped series of synaptic events in rat and human cortical networks because of a depolarized reversal potential for axonal relative to perisomatic GABAergic inputs. Excitation and signal propagation initiated by AACs is supported by the absence of the potassium chloride cotransporter 2 in the axon.
Similar articles
- Properties of horizontal axo-axonic cells in stratum oriens of the hippocampal CA1 area of rats in vitro.
Ganter P, Szücs P, Paulsen O, Somogyi P. Ganter P, et al. Hippocampus. 2004;14(2):232-43. doi: 10.1002/hipo.10170. Hippocampus. 2004. PMID: 15098728 - A new cellular mechanism for coupling inputs arriving at different cortical layers.
Larkum ME, Zhu JJ, Sakmann B. Larkum ME, et al. Nature. 1999 Mar 25;398(6725):338-41. doi: 10.1038/18686. Nature. 1999. PMID: 10192334 - Input and frequency-specific entrainment of postsynaptic firing by IPSPs of perisomatic or dendritic origin.
Tamás G, Szabadics J, Lörincz A, Somogyi P. Tamás G, et al. Eur J Neurosci. 2004 Nov;20(10):2681-90. doi: 10.1111/j.1460-9568.2004.03719.x. Eur J Neurosci. 2004. PMID: 15548211 - GABAergic control of CA3-driven network events in the developing hippocampus.
Sipilä ST, Kaila K. Sipilä ST, et al. Results Probl Cell Differ. 2008;44:99-121. doi: 10.1007/400_2007_033. Results Probl Cell Differ. 2008. PMID: 17622497 Review. - GABAergic control of substantia nigra dopaminergic neurons.
Tepper JM, Lee CR. Tepper JM, et al. Prog Brain Res. 2007;160:189-208. doi: 10.1016/S0079-6123(06)60011-3. Prog Brain Res. 2007. PMID: 17499115 Review.
Cited by
- Short-term ionic plasticity at GABAergic synapses.
Raimondo JV, Markram H, Akerman CJ. Raimondo JV, et al. Front Synaptic Neurosci. 2012 Oct 16;4:5. doi: 10.3389/fnsyn.2012.00005. eCollection 2012. Front Synaptic Neurosci. 2012. PMID: 23087642 Free PMC article. - Location-dependent effects of inhibition on local spiking in pyramidal neuron dendrites.
Jadi M, Polsky A, Schiller J, Mel BW. Jadi M, et al. PLoS Comput Biol. 2012;8(6):e1002550. doi: 10.1371/journal.pcbi.1002550. Epub 2012 Jun 14. PLoS Comput Biol. 2012. PMID: 22719240 Free PMC article. - Altered cortical GABA neurotransmission in schizophrenia: insights into novel therapeutic strategies.
Stan AD, Lewis DA. Stan AD, et al. Curr Pharm Biotechnol. 2012 Jun;13(8):1557-62. doi: 10.2174/138920112800784925. Curr Pharm Biotechnol. 2012. PMID: 22283765 Free PMC article. Review. - Molecular and Electrophysiological Characterization of GABAergic Interneurons Expressing the Transcription Factor COUP-TFII in the Adult Human Temporal Cortex.
Varga C, Tamas G, Barzo P, Olah S, Somogyi P. Varga C, et al. Cereb Cortex. 2015 Nov;25(11):4430-49. doi: 10.1093/cercor/bhv045. Epub 2015 Mar 18. Cereb Cortex. 2015. PMID: 25787832 Free PMC article. - Dense and overlapping innervation of pyramidal neurons by chandelier cells.
Inan M, Blázquez-Llorca L, Merchán-Pérez A, Anderson SA, DeFelipe J, Yuste R. Inan M, et al. J Neurosci. 2013 Jan 30;33(5):1907-14. doi: 10.1523/JNEUROSCI.4049-12.2013. J Neurosci. 2013. PMID: 23365230 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources