A review of the effects of insulin-like growth factor and platelet derived growth factor on in vivo cartilage healing and repair - PubMed (original) (raw)
Review
doi: 10.1016/j.joca.2005.10.011. Epub 2006 Jan 18.
Affiliations
- PMID: 16413799
- DOI: 10.1016/j.joca.2005.10.011
Free article
Review
A review of the effects of insulin-like growth factor and platelet derived growth factor on in vivo cartilage healing and repair
M B Schmidt et al. Osteoarthritis Cartilage. 2006 May.
Free article
Abstract
Growth factors may enhance current cartilage repair techniques via multiple mechanisms including recruitment of chondrogenic cells (chemotaxis), stimulation of chondrogenic cell proliferation (mitogenesis) and enhancement of cartilage matrix synthesis. Two growth factors that have been studied in cartilage repair are insulin-like growth factor (IGF) and platelet derived growth factor (PDGF). IGF plays a key role in cartilage homeostasis, balancing proteoglycan synthesis and breakdown. Incorporating IGF into a fibrin clot placed in an equine cartilage defect improved the quality and quantity of repair tissue and reduced synovial inflammation. PDGF is a potent mitogenic and chemotactic factor for all cells of mesenchymal origin, including chondrocytes and mesenchymal stem cells. Resting zone chondrocytes cultured with PDGF demonstrated increased cell proliferation and proteoglycan production, while maturation of these cells along the endochondral pathway was inhibited. Pretreating chondrocytes with PDGF promotes heterotopic cartilage formation in the absence of any mechanical stimulus. PDGF has also been shown to be a potent stimulator of meniscal cell proliferation and migration. These studies and others suggest a potential role for these potent biological regulators of chondrocytes in cartilage repair. More work needs to be performed to define their appropriate dosing and the optimum delivery method. Combining tissue growth factors with a biological matrix can provide a physical scaffold for cell adhesion and growth as well as a means to control the release of these potent molecules. This could result in biological devices that enhance the predictability and quality of current cartilage repair techniques.
Similar articles
- Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model.
Goodrich LR, Hidaka C, Robbins PD, Evans CH, Nixon AJ. Goodrich LR, et al. J Bone Joint Surg Br. 2007 May;89(5):672-85. doi: 10.1302/0301-620X.89B5.18343. J Bone Joint Surg Br. 2007. PMID: 17540757 - Growth factors in cartilage and meniscus repair.
Forriol F. Forriol F. Injury. 2009 Dec;40 Suppl 3:S12-6. doi: 10.1016/S0020-1383(09)70005-1. Injury. 2009. PMID: 20082784 - Clinical applications of growth factors for articular cartilage repair.
Hickey DG, Frenkel SR, Di Cesare PE. Hickey DG, et al. Am J Orthop (Belle Mead NJ). 2003 Feb;32(2):70-6. Am J Orthop (Belle Mead NJ). 2003. PMID: 12602635 Review. - [The structure, physiology, and biomechanics of articular cartilage: injury and repair].
Tatari H. Tatari H. Acta Orthop Traumatol Turc. 2007;41 Suppl 2:1-5. Acta Orthop Traumatol Turc. 2007. PMID: 18180577 Review. Turkish.
Cited by
- Over-Production of Therapeutic Growth Factors for Articular Cartilage Regeneration by Protein Production Platforms and Protein Packaging Cell Lines.
Mobasheri A, Choi H, Martín-Vasallo P. Mobasheri A, et al. Biology (Basel). 2020 Oct 9;9(10):330. doi: 10.3390/biology9100330. Biology (Basel). 2020. PMID: 33050357 Free PMC article. Review. - Scaffold-Mediated Gene Delivery for Osteochondral Repair.
Madry H, Venkatesan JK, Carballo-Pedrares N, Rey-Rico A, Cucchiarini M. Madry H, et al. Pharmaceutics. 2020 Sep 29;12(10):930. doi: 10.3390/pharmaceutics12100930. Pharmaceutics. 2020. PMID: 33003607 Free PMC article. Review. - GAAGs, COMP, and YKL-40 as Potential Markers of Cartilage Turnover in Blood of Children with Juvenile Idiopathic Arthritis Treated with Etanercept-Relationship with ADAMTS4, ADAMTS5, and PDGF-BB.
Dąbkowska K, Wojdas M, Kuźnik-Trocha K, Wisowski G, Gruenpeter A, Komosińska-Vassev K, Olczyk K, Winsz-Szczotka K. Dąbkowska K, et al. J Clin Med. 2022 Aug 29;11(17):5069. doi: 10.3390/jcm11175069. J Clin Med. 2022. PMID: 36079004 Free PMC article. - Comparison of the effect of growth factors on chondrogenesis of canine mesenchymal stem cells.
Endo K, Fujita N, Nakagawa T, Nishimura R. Endo K, et al. J Vet Med Sci. 2019 Aug 24;81(8):1211-1218. doi: 10.1292/jvms.18-0551. Epub 2019 Jun 4. J Vet Med Sci. 2019. PMID: 31167981 Free PMC article. - Interleukin-1 beta and tumor necrosis factor alpha inhibit migration activity of chondrogenic progenitor cells from non-fibrillated osteoarthritic cartilage.
Joos H, Wildner A, Hogrefe C, Reichel H, Brenner RE. Joos H, et al. Arthritis Res Ther. 2013;15(5):R119. doi: 10.1186/ar4299. Arthritis Res Ther. 2013. PMID: 24034344 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources