Bidirectional behavioral plasticity of memory reconsolidation depends on amygdalar protein kinase A - PubMed (original) (raw)
doi: 10.1038/nn1628. Epub 2006 Jan 15.
Affiliations
- PMID: 16415868
- DOI: 10.1038/nn1628
Bidirectional behavioral plasticity of memory reconsolidation depends on amygdalar protein kinase A
Natalie C Tronson et al. Nat Neurosci. 2006 Feb.
Abstract
Reconsolidation-the stabilization of a memory after retrieval-is hypothesized to be a critical and distinct component of memory processing, the disruption of which results in memory impairment. In the rat, we found that activation of amygdalar protein kinase A (PKA) was sufficient to enhance memory only when it was retrieved; in contrast, PKA inhibition impaired reconsolidation. This study demonstrates both a selective enhancement and an impairment of memory reconsolidation dependent on amygdalar PKA.
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