Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants - PubMed (original) (raw)
doi: 10.1038/nm1340. Epub 2006 Jan 15.
Nicole Huttary, Ingrid Raab, Heinz Regele, Katalin Bojarski-Nagy, Gregor Bartel, Stefan M Kröber, Hildegard Greinix, Agathe Rosenmaier, Franz Karlhofer, Nikolaus Wick, Peter R Mazal
Affiliations
- PMID: 16415878
- DOI: 10.1038/nm1340
Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants
Dontscho Kerjaschki et al. Nat Med. 2006 Feb.
Abstract
De novo lymphangiogenesis influences the course of different human diseases as diverse as chronic renal transplant rejection and tumor metastasis. The cellular mechanisms of lymphangiogenesis in human diseases are currently unknown, and could involve division of local preexisting endothelial cells or incorporation of circulating progenitors. We analyzed renal tissues of individuals with gender-mismatched transplants who had transplant rejection and high rates of overall lymphatic endothelial proliferation as well as massive chronic inflammation. Donor-derived cells were detected by in situ hybridization of the Y chromosome. We compared these tissues with biopsies of essentially normal skin and intestine, and two rare carcinomas with low rates of lymphatic endothelial proliferation that were derived from individuals with gender-mismatched bone marrow transplants. Here, we provide evidence for the participation of recipient-derived lymphatic progenitor cells in renal transplants. In contrast, lymphatic vessels of normal tissues and those around post-transplant carcinomas did not incorporate donor-derived progenitors. This indicates a stepwise mechanism of inflammation-associated de novo lymphangiogenesis, implying that potential lymphatic progenitor cells derive from the circulation, transmigrate through the connective tissue stroma, presumably in the form of macrophages, and finally incorporate into the growing lymphatic vessel.
Similar articles
- Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis.
He Y, Rajantie I, Ilmonen M, Makinen T, Karkkainen MJ, Haiko P, Salven P, Alitalo K. He Y, et al. Cancer Res. 2004 Jun 1;64(11):3737-40. doi: 10.1158/0008-5472.CAN-04-0088. Cancer Res. 2004. PMID: 15172976 - Endothelial cell chimerism by fluorescence in situ hybridization in gender mismatched renal allograft biopsies.
Bai HW, Shi BY, Qian YY, Na YQ, Zeng X, Zhong DR, Lu M, Zou WZ, Wu SF. Bai HW, et al. Chin Med J (Engl). 2007 May 20;120(10):859-62. Chin Med J (Engl). 2007. PMID: 17543173 - Tubular and endothelial chimerism in renal allografts using fluorescence and chromogenic in situ hybridization (FISH, CISH) technology.
Varga Z, Gaspert A, Behnke S, von Teichman A, Fritzsche F, Fehr T. Varga Z, et al. Pathol Int. 2012 Apr;62(4):254-63. doi: 10.1111/j.1440-1827.2012.02803.x. Epub 2012 Mar 4. Pathol Int. 2012. PMID: 22449229 - Molecular control of lymphatic metastasis.
Achen MG, Stacker SA. Achen MG, et al. Ann N Y Acad Sci. 2008;1131:225-34. doi: 10.1196/annals.1413.020. Ann N Y Acad Sci. 2008. PMID: 18519975 Review. - Lymphatic neoangiogenesis in renal transplants: a driving force of chronic rejection?
Kerjaschki D. Kerjaschki D. J Nephrol. 2006 Jul-Aug;19(4):403-6. J Nephrol. 2006. PMID: 17048196 Review.
Cited by
- Myeloid cells and lymphangiogenesis.
Zumsteg A, Christofori G. Zumsteg A, et al. Cold Spring Harb Perspect Med. 2012 Jun;2(6):a006494. doi: 10.1101/cshperspect.a006494. Cold Spring Harb Perspect Med. 2012. PMID: 22675661 Free PMC article. Review. - Lymphangiogenesis and lymphatic metastasis in breast cancer.
Ran S, Volk L, Hall K, Flister MJ. Ran S, et al. Pathophysiology. 2010 Sep;17(4):229-51. doi: 10.1016/j.pathophys.2009.11.003. Epub 2009 Dec 24. Pathophysiology. 2010. PMID: 20036110 Free PMC article. - Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing.
Maruyama K, Asai J, Ii M, Thorne T, Losordo DW, D'Amore PA. Maruyama K, et al. Am J Pathol. 2007 Apr;170(4):1178-91. doi: 10.2353/ajpath.2007.060018. Am J Pathol. 2007. PMID: 17392158 Free PMC article. - Biomarkers of lymphatic function and disease: state of the art and future directions.
Nakamura K, Rockson SG. Nakamura K, et al. Mol Diagn Ther. 2007;11(4):227-38. doi: 10.1007/BF03256244. Mol Diagn Ther. 2007. PMID: 17705577 Review. - Myeloid cells in cancer progression: unique subtypes and their roles in tumor growth, vascularity, and host immune suppression.
Young PP, Ardestani S, Li B. Young PP, et al. Cancer Microenviron. 2010 Apr 20;4(1):1-11. doi: 10.1007/s12307-010-0045-4. Cancer Microenviron. 2010. PMID: 21505557 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical