Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian Yoruba - PubMed (original) (raw)

. 2006 Jan 24;66(2):223-7.

doi: 10.1212/01.wnl.0000194507.39504.17.

J Murrell, A Ogunniyi, M Deeg, O Baiyewu, S Gao, O Gureje, J Dickens, R Evans, V Smith-Gamble, F W Unverzagt, J Shen, H Hendrie

Affiliations

Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian Yoruba

K Hall et al. Neurology. 2006.

Abstract

Objective: To examine the relationship between cholesterol and other lipids, APOE genotype, and risk of Alzheimer disease (AD) in a population-based study of elderly Yoruba living in Ibadan, Nigeria.

Methods: Blood samples and clinical data were collected from Yoruba study participants aged 70 years and older (N = 1,075) as part of the Indianapolis-Ibadan Dementia Project, a longitudinal epidemiologic study of AD. Cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride levels were measured in fasting blood samples. DNA was extracted and APOE was genotyped. Diagnoses of AD were made by consensus using National Institute of Neurologic Disorders/Stroke-Alzheimer's Disease and Related Disorders Association criteria.

Results: Logistic regression models showed interaction after adjusting for age and gender between APOE-epsilon4 genotype and biomarkers in the risk of AD cholesterol*genotype (p = 0.022), LDL*genotype (p= 0.018), and triglyceride*genotype (p = 0.036). Increasing levels of cholesterol and LDL were associated with increased risk of AD in individuals without the APOE-epsilon4 allele, but not in those with APOE-epsilon4. There was no significant association between levels of triglycerides and AD risk in those without APOE-epsilon4.

Conclusions: There was a significant interaction between cholesterol, APOE-epsilon4, and the risk of Alzheimer disease (AD) in the Yoruba, a population that has lower cholesterol levels and lower incidence rates of AD compared to African Americans. APOE status needs to be considered when assessing the relationship between lipid levels and AD risk in population studies.

PubMed Disclaimer

Conflict of interest statement

Disclosure: The authors report no conflicts of interest.

Figures

Figure

Figure. Predicted log ORs of AD risk vs cholesterol level by APOE-ε4 group. This graph shows an interaction between cholesterol and APOE. For individuals without ε4, there was an increased risk of AD with higher cholesterol levels

Similar articles

Cited by

References

    1. Farrer LA, Cupples LA, Haines JL, et al. Effects of age, gender and ethnicity on the association between apolipoprotein-E genotype and Alzheimer's disease. JAMA. 1997;278:1349–1356. - PubMed
    1. Evans DA, Bennett DA, Wilson RS, et al. Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status. Arch Neurol. 2003;60:161–163. - PubMed
    1. Tang MX, Stern Y, Marder K, et al. The APOE-epsilon 4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics. JAMA. 1998;279:751–755. - PubMed
    1. Sahota A, Yang M, Gao S, et al. Apolipoprotein E-associated risk for Alzheimer disease in the African-American population is genotype dependent. Ann Neurol. 1997;42:659–661. - PubMed
    1. Osuntokun BO, Sahota A, Ogunniyi AO, et al. Lack of an association between the apolipoprotein E e4 allele and Alzheimer's disease in elderly Nigerians. Ann Neurol. 1995;38:463–465. - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources