Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus - PubMed (original) (raw)

Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus

Inshad Ali Khan et al. Antimicrob Agents Chemother. 2006 Feb.

Abstract

Piperine, a trans-trans isomer of 1-piperoyl-piperidine, in combination with ciprofloxacin markedly reduced the MICs and mutation prevention concentration of ciprofloxacin for Staphylococcus aureus, including methicillin-resistant S. aureus. The enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIPr-1) strains in the presence of piperine suggest its involvement in the inhibition of bacterial efflux pumps.

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Figures

FIG. 1.

Accumulation (A) and efflux (B) of ethidium bromide in wild-type and mutant (CIPr-1) strains and effect of piperine (25 μg/ml) thereon.

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References

1. 1. Atal, C. K., R. K. Dubey, and J. Singh. 1985. Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism. J. Pharmacol. Exp. Ther. 232:258-262. - PubMed
2. 1. Atal, C. K., U. Zutshi, and P. G. Rao. 1981. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. J. Ethnopharmacol. 4:229-232. - PubMed
3. 1. Badmaev, V., M. Majeed, and E. P. Norkus. 1999. Piperine, an alkaloid derived from black pepper, increases serum response of beta-carotene during 14 days of oral beta-carotene supplementation. Nutr. Res. 19:381-388.
4. 1. Baranova, N., and A. A. Neyfakh. 1997. Apparent involvement of a multidrug transporter in the fluoroquinolones resistance of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 41:1396-1398. - PMC - PubMed
5. 1. Bhardwaj, R. K., H. Glaeser, L. Becquemont, U. Klotz, S. K. Gupta, and M. F. Fromm. 2002. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J. Pharmacol. Exp. Ther. 302:645-650. - PubMed

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