Myocardial homing and neovascularization by human bone marrow angioblasts is regulated by IL-8/Gro CXC chemokines - PubMed (original) (raw)
doi: 10.1016/j.yjmcc.2005.11.013. Epub 2006 Jan 24.
M D Schuster, N Bonaros, K Lietz, G Xiang, T P Martens, P A Kurlansky, H Sondermeijer, P Witkowski, A Boyle, S Homma, S F Wang, S Itescu
Affiliations
- PMID: 16438981
- DOI: 10.1016/j.yjmcc.2005.11.013
Myocardial homing and neovascularization by human bone marrow angioblasts is regulated by IL-8/Gro CXC chemokines
A A Kocher et al. J Mol Cell Cardiol. 2006 Apr.
Abstract
In the adult, new blood vessel formation can occur either through angiogenesis from pre-existing mature endothelium or vasculogenesis mediated by bone marrow-derived endothelial precursors. We recently isolated endothelial progenitor cells, or angioblasts, in human adult bone marrow which have selective migratory properties for ischemic tissues, including myocardium, to where they home and induce vasculogenesis. Here we show that myocardial production of the IL-8/Gro-alpha CXC chemokine family is significantly increased after acute ischemia, and that this provides a chemoattractant gradient for bone marrow-derived endothelial progenitors, or angioblasts. This chemokine-mediated homing of bone marrow angioblasts to the ischemic heart regulates their ability to induce myocardial neovascularization, protection against cardiomyocyte apoptosis, and functional cardiac recovery. Together, our results indicate that CXC chemokines play a central role in regulating vasculogenesis in the adult, and suggest that manipulation of interactions between chemokines and their receptors on autologous human bone marrow-derived angioblasts could augment neovascularization of ischemic myocardial tissue.
Comment in
- IL-8: a new player in the homing of endothelial progenitor cells to ischemic myocardium.
Chavakis E. Chavakis E. J Mol Cell Cardiol. 2006 Apr;40(4):442-5. doi: 10.1016/j.yjmcc.2006.01.014. Epub 2006 Mar 6. J Mol Cell Cardiol. 2006. PMID: 16516915 No abstract available.
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