Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow - PubMed (original) (raw)
. 2006 Jan 27;124(2):407-21.
doi: 10.1016/j.cell.2005.10.041.
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- PMID: 16439213
- DOI: 10.1016/j.cell.2005.10.041
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Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow
Yoshio Katayama et al. Cell. 2006.
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Abstract
Hematopoietic stem and progenitor cells (HSPC), attracted by the chemokine CXCL12, reside in specific niches in the bone marrow (BM). HSPC migration out of the BM is a critical process that underlies modern clinical stem cell transplantation. Here we demonstrate that enforced HSPC egress from BM niches depends critically on the nervous system. UDP-galactose ceramide galactosyltransferase-deficient (Cgt(-/-)) mice exhibit aberrant nerve conduction and display virtually no HSPC egress from BM following granulocyte colony-stimulating factor (G-CSF) or fucoidan administration. Adrenergic tone, osteoblast function, and bone CXCL12 are dysregulated in Cgt(-/-) mice. Pharmacological or genetic ablation of adrenergic neurotransmission indicates that norepinephrine (NE) signaling controls G-CSF-induced osteoblast suppression, bone CXCL12 downregulation, and HSPC mobilization. Further, administration of a beta(2) adrenergic agonist enhances mobilization in both control and NE-deficient mice. Thus, these results indicate that the sympathetic nervous system regulates the attraction of stem cells to their niche.
Comment in
- Nervous activity in a stem cell niche.
Larsson J, Scadden D. Larsson J, et al. Cell. 2006 Jan 27;124(2):253-5. doi: 10.1016/j.cell.2006.01.006. Cell. 2006. PMID: 16439198 Review.
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