Peroxisome-proliferator-activated receptor-gamma (PPARgamma) activation protects neurons from NMDA excitotoxicity - PubMed (original) (raw)
Comparative Study
. 2006 Feb 16:1073-1074:460-9.
doi: 10.1016/j.brainres.2005.12.061. Epub 2006 Jan 25.
Affiliations
- PMID: 16442504
- DOI: 10.1016/j.brainres.2005.12.061
Comparative Study
Peroxisome-proliferator-activated receptor-gamma (PPARgamma) activation protects neurons from NMDA excitotoxicity
Xiurong Zhao et al. Brain Res. 2006.
Abstract
A growing body of evidence indicates that the transcription factor PPARgamma plays a beneficial role in various neurological diseases. The postulated principal mechanism underlying the beneficial effects of PPARgamma is due to its anti-inflammatory properties. However, PPARgamma exists in neurons where it may provide additional effects that regulate neuronal vulnerability. In the present study, we employed in vitro and in vivo models of excitotoxic neuronal injury to test hypothesis on the neuroprotective role of PPARgamma. The endogenous PPARgamma ligand, 15d-Delta(12,14)-Prostaglandin J2 (15d-PGJ2), and a selective thiazolidinedione PPARgamma agonist, ciglitazone, significantly reduced neuronal death in response to glutamate and NMDA-mediated, but not kainate-mediated toxicity. This neuroprotective effect of 15d-PGJ2 and ciglitazone was linked to increased PPARgamma DNA binding activity as it was fully reversed by the pretreatment of neurons with selective PPARgamma antagonists and anti-PPARgamma antibody. It was not due to the blockade of NMDA-receptor-mediated Ca++ entry. Our data demonstrate that PPARgamma activation may represent a potential target for treatment of numerous acute and chronic neurological diseases with pathologies that involve excitotoxic damage.
Similar articles
- 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) protects neurons from oxidative death via an Nrf2 astrocyte-specific mechanism independent of PPARγ.
Haskew-Layton RE, Payappilly JB, Xu H, Bennett SA, Ratan RR. Haskew-Layton RE, et al. J Neurochem. 2013 Feb;124(4):536-47. doi: 10.1111/jnc.12107. Epub 2013 Jan 3. J Neurochem. 2013. PMID: 23199167 - The excitoprotective effect of N-methyl-D-aspartate receptors is mediated by a brain-derived neurotrophic factor autocrine loop in cultured hippocampal neurons.
Jiang X, Tian F, Mearow K, Okagaki P, Lipsky RH, Marini AM. Jiang X, et al. J Neurochem. 2005 Aug;94(3):713-22. doi: 10.1111/j.1471-4159.2005.03200.x. Epub 2005 Jul 5. J Neurochem. 2005. PMID: 16000165 - Hydroxysafflor Yellow A Shows Protection against PPAR_γ_ Inactivation in Nitrosative Neurons.
Sun L, Xu YW, Han J, Xiao C, Cao SS, Liang H, Cheng Y. Sun L, et al. Oxid Med Cell Longev. 2018 Oct 16;2018:9101740. doi: 10.1155/2018/9101740. eCollection 2018. Oxid Med Cell Longev. 2018. PMID: 30410641 Free PMC article. - Protection of cultured rat cortical neurons from excitotoxicity by asarone, a major essential oil component in the rhizomes of Acorus gramineus.
Cho J, Kim YH, Kong JY, Yang CH, Park CG. Cho J, et al. Life Sci. 2002 Jun 21;71(5):591-9. doi: 10.1016/s0024-3205(02)01729-0. Life Sci. 2002. PMID: 12052443 - PPAR_γ_ in Bacterial Infections: A Friend or Foe?
Reddy AT, Lakshmi SP, Reddy RC. Reddy AT, et al. PPAR Res. 2016;2016:7963540. doi: 10.1155/2016/7963540. Epub 2016 Sep 28. PPAR Res. 2016. PMID: 27774097 Free PMC article. Review.
Cited by
- Protective effects of pioglitazone in renal ischemia-reperfusion injury (RIRI): focus on oxidative stress and inflammation.
Golmohammadi M, Ivraghi MS, Hasan EK, Huldani H, Zamanian MY, Rouzbahani S, Mustafa YF, Al-Hasnawi SS, Alazbjee AAA, Khalajimoqim F, Khalaj F. Golmohammadi M, et al. Clin Exp Nephrol. 2024 Oct;28(10):955-968. doi: 10.1007/s10157-024-02525-3. Epub 2024 Jun 27. Clin Exp Nephrol. 2024. PMID: 38935212 Review. - Expression of Cannabinoid Receptors in the Trigeminal Ganglion of the Horse.
Zamith Cunha R, Semprini A, Salamanca G, Gobbo F, Morini M, Pickles KJ, Roberts V, Chiocchetti R. Zamith Cunha R, et al. Int J Mol Sci. 2023 Nov 3;24(21):15949. doi: 10.3390/ijms242115949. Int J Mol Sci. 2023. PMID: 37958932 Free PMC article. - Discovering Venom-Derived Drug Candidates Using Differential Gene Expression.
Romano JD, Li H, Napolitano T, Realubit R, Karan C, Holford M, Tatonetti NP. Romano JD, et al. Toxins (Basel). 2023 Jul 9;15(7):451. doi: 10.3390/toxins15070451. Toxins (Basel). 2023. PMID: 37505720 Free PMC article. - Phytohormone abscisic acid elicits positive effects on harmaline-induced cognitive and motor disturbances in a rat model of essential tremor.
Shabani M, Naderi R. Shabani M, et al. Brain Behav. 2022 May;12(5):e2564. doi: 10.1002/brb3.2564. Epub 2022 Apr 5. Brain Behav. 2022. PMID: 35591769 Free PMC article. - Glutamate-Gated NMDA Receptors: Insights into the Function and Signaling in the Kidney.
Valdivielso JM, Eritja À, Caus M, Bozic M. Valdivielso JM, et al. Biomolecules. 2020 Jul 15;10(7):1051. doi: 10.3390/biom10071051. Biomolecules. 2020. PMID: 32679780 Free PMC article. Review.