Dual origin of avian lymphatics - PubMed (original) (raw)
Comparative Study
. 2006 Apr 1;292(1):165-73.
doi: 10.1016/j.ydbio.2005.12.043. Epub 2006 Feb 2.
Affiliations
- PMID: 16457798
- DOI: 10.1016/j.ydbio.2005.12.043
Free article
Comparative Study
Dual origin of avian lymphatics
Jörg Wilting et al. Dev Biol. 2006.
Free article
Abstract
The earliest signs of the lymphatic vascular system are the lymph sacs, which develop adjacent to specific embryonic veins. It has been suggested that sprouts from the lymph sacs form the complete lymphatic vascular system. We have studied the origin of the jugular lymph sacs (JLS), the dermal lymphatics and the lymph hearts of avian embryos. In day 6.5 embryos, the JLS is an endothelial-lined sinusoidal structure. The lymphatic endothelial cells (LECs) stain (in the quail) positive for QH1 antibody and soybean agglutinin. As early as day 4, the anlagen of the JLS can be recognized by their Prox1 expression. Prox1 is found in the jugular section of the cardinal veins, and in scattered cells located in the dermatomes along the cranio-caudal axis and in the splanchnopleura. In the quail, such cells are positive for Prox1 and QH1. In the jugular region, the veins co-express the angiopoietin receptor Tie2. Quail-chick-chimera studies show that the peripheral parts of the JLS form by integration of cells from the paraxial mesoderm. Intra-venous application of DiI-conjugated acetylated low-density lipoprotein into day 4 embryos suggests a venous origin of the deep parts of the JLS. Superficial lymphatics are directly derived from the dermatomes, as shown by dermatome grafting. The lymph hearts in the lumbo-sacral region develop from a plexus of Prox1-positive lymphatic capillaries. Both LECs and muscle cells of the lymph hearts are of somitic origin. In sum, avian lymphatics are of dual origin. The deep parts of the lymph sacs are derived from adjacent veins, the superficial parts of the JLS and the dermal lymphatics from local lymphangioblasts.
Similar articles
- Lymphangioblasts in the avian wing bud.
Schneider M, Othman-Hassan K, Christ B, Wilting J. Schneider M, et al. Dev Dyn. 1999 Dec;216(4-5):311-9. doi: 10.1002/(SICI)1097-0177(199912)216:4/5<311::AID-DVDY1>3.0.CO;2-M. Dev Dyn. 1999. PMID: 10633852 - Development of the avian lymphatic system.
Wilting J, Papoutsi M, Othman-Hassan K, Rodriguez-Niedenführ M, Pröls F, Tomarev SI, Eichmann A. Wilting J, et al. Microsc Res Tech. 2001 Oct 15;55(2):81-91. doi: 10.1002/jemt.1159. Microsc Res Tech. 2001. PMID: 11596153 - Transcription factor FOXC2 demarcates the jugular lymphangiogenic region in avian embryos.
Rutscher K, Wilting J. Rutscher K, et al. Lymphology. 2008 Mar;41(1):11-7. Lymphology. 2008. PMID: 18581954 - Prox1, master regulator of the lymphatic vasculature phenotype.
Hong YK, Detmar M. Hong YK, et al. Cell Tissue Res. 2003 Oct;314(1):85-92. doi: 10.1007/s00441-003-0747-8. Epub 2003 Jul 22. Cell Tissue Res. 2003. PMID: 12883994 Review. - [Emergence of the endothelial network during embryonic development].
Dieterlen-Lièvre F, Jaffredo T, Pardanaud L. Dieterlen-Lièvre F, et al. Pathol Biol (Paris). 1999 Apr;47(4):301-6. Pathol Biol (Paris). 1999. PMID: 10372397 Review. French.
Cited by
- The cardiopharyngeal mesoderm contributes to lymphatic vessel development in mouse.
Maruyama K, Miyagawa-Tomita S, Haneda Y, Kida M, Matsuzaki F, Imanaka-Yoshida K, Kurihara H. Maruyama K, et al. Elife. 2022 Oct 5;11:e81515. doi: 10.7554/eLife.81515. Elife. 2022. PMID: 36196867 Free PMC article. - Elevated expression of VEGFR-3 in lymphatic endothelial cells from lymphangiomas.
Norgall S, Papoutsi M, Rössler J, Schweigerer L, Wilting J, Weich HA. Norgall S, et al. BMC Cancer. 2007 Jun 21;7:105. doi: 10.1186/1471-2407-7-105. BMC Cancer. 2007. PMID: 17584927 Free PMC article. - The Enigmas of Lymphatic Muscle Cells: Where Do They Come From, How Are They Maintained, and Can They Regenerate?
Kenney HM, Peng Y, de Mesy Bentley KL, Xing L, Ritchlin CT, Schwarz EM. Kenney HM, et al. Curr Rheumatol Rev. 2023 Jun 5;19(3):246-259. doi: 10.2174/1573397119666230127144711. Curr Rheumatol Rev. 2023. PMID: 36705238 Free PMC article. Review. - Absence of lymphatic vessels in term placenta.
Becker J, Tchagou Tchangou GE, Schmidt S, Zelent C, Kahl F, Wilting J. Becker J, et al. BMC Pregnancy Childbirth. 2020 Jun 29;20(1):380. doi: 10.1186/s12884-020-03073-w. BMC Pregnancy Childbirth. 2020. PMID: 32600346 Free PMC article. - Formation and Growth of Cardiac Lymphatics during Embryonic Development, Heart Regeneration, and Disease.
Gancz D, Perlmoter G, Yaniv K. Gancz D, et al. Cold Spring Harb Perspect Biol. 2020 Jun 1;12(6):a037176. doi: 10.1101/cshperspect.a037176. Cold Spring Harb Perspect Biol. 2020. PMID: 31818858 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous