Spread of Staphylococcus aureus clinical isolates carrying Panton-Valentine leukocidin genes during a 3-year period in Greece - PubMed (original) (raw)

Spread of Staphylococcus aureus clinical isolates carrying Panton-Valentine leukocidin genes during a 3-year period in Greece

V Chini et al. Clin Microbiol Infect. 2006 Jan.

Free article

Abstract

Three collections of Staphylococcus aureus isolates (n = 1,058) were investigated to assess the spread of Panton-Valentine leukocidin (PVL)-producing strains in Greece and their association with skin and soft-tissue infections (SSTIs). The isolates were collected during 2001-2003 from inpatients and outpatients with invasive infections in two distinct geographical areas. Clonal types were identified according to their ClaI-mecA::ClaI-Tn554::pulsed-field gel electrophoresis patterns, and the presence of the lukS-PV and lukF-PV genes was assessed by PCR. In total, 287 (27%) S. aureus isolates carried the PVL genes: 45% of methicillin-resistant S. aureus (MRSA) and 12% of methicillin-sensitive S. aureus (MSSA). All the PVL-positive MRSA isolates belonged to a single clone that was disseminated in the community and hospitals. The PVL-positive MSSA isolates were polyclonal, with 14 of 65 isolates being associated with hospital-acquired infections. The community-acquired isolates were from SSTIs, while the hospital-acquired isolates were associated with surgical wound infections, especially those involving prosthetic devices. Thus, a unique clone of PVL-positive MRSA has spread in both the community and the hospital setting in Greece, and has replaced older clonal types.

PubMed Disclaimer

Cited by

Prevalence of mecA and Panton-Valentine Leukocidin Genes in Staphylococcus aureus Clinical Isolates from Gaza Strip Hospitals.
El Aila NA, Al Laham NA, Naas T. El Aila NA, et al. Microorganisms. 2023 Apr 28;11(5):1155. doi: 10.3390/microorganisms11051155. Microorganisms. 2023. PMID: 37317129 Free PMC article.
Examining the Prevalence and Antibiotic Susceptibility of S. aureus Strains in Hospitals: An Analysis of the pvl Gene and Its Co-Occurrence with Other Virulence Factors.
Vittorakis E, Vică ML, Zervaki CO, Vittorakis E, Maraki S, Mavromanolaki VE, Schürger ME, Neculicioiu VS, Papadomanolaki E, Sinanis T, Giannoulaki G, Xydaki E, Kastanakis SG, Junie LM. Vittorakis E, et al. Microorganisms. 2023 Mar 25;11(4):841. doi: 10.3390/microorganisms11040841. Microorganisms. 2023. PMID: 37110264 Free PMC article.
MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework.
Shoaib M, Aqib AI, Muzammil I, Majeed N, Bhutta ZA, Kulyar MF, Fatima M, Zaheer CF, Muneer A, Murtaza M, Kashif M, Shafqat F, Pu W. Shoaib M, et al. Front Microbiol. 2023 Jan 10;13:1067284. doi: 10.3389/fmicb.2022.1067284. eCollection 2022. Front Microbiol. 2023. PMID: 36704547 Free PMC article. Review.
Staphylococcus aureus Keratitis in Taiwan: Genotyping, Antibiotic Susceptibility, and Clinical Features.
Hsiao CH, Kang EY, Yeh LK, Ma DHK, Chen HC, Hung KH, Huang YC. Hsiao CH, et al. Int J Mol Sci. 2022 Oct 3;23(19):11703. doi: 10.3390/ijms231911703. Int J Mol Sci. 2022. PMID: 36233005 Free PMC article.
Emergence of a mupirocin-resistant, methicillin-susceptible Staphylococcus aureus clone associated with skin and soft tissue infections in Greece.
Giormezis N, Doudoulakakis A, Tsilipounidaki K, Militsopoulou M, Kalogeras G, Stamouli V, Kolonitsiou F, Petinaki E, Lebessi E, Spiliopoulou I. Giormezis N, et al. BMC Microbiol. 2021 Jul 3;21(1):203. doi: 10.1186/s12866-021-02272-5. BMC Microbiol. 2021. PMID: 34215177 Free PMC article.

Spread of Staphylococcus aureus clinical isolates carrying Panton-Valentine leukocidin genes during a 3-year period in Greece - PubMed (original) (raw)