Corticolimbic blood flow during nontraumatic emotional processing in posttraumatic stress disorder - PubMed (original) (raw)
Comparative Study
Corticolimbic blood flow during nontraumatic emotional processing in posttraumatic stress disorder
K Luan Phan et al. Arch Gen Psychiatry. 2006 Feb.
Abstract
Context: Recent brain imaging studies implicate dysfunction of limbic and paralimbic circuitry, including the amygdala and medial prefrontal cortex (MPFC), in the pathogenesis of posttraumatic stress disorder (PTSD) during traumatic recollection and imagery. However, the relationship between activity in these regions and general emotional processing unrelated to traumatic experience has not been fully examined.
Objective: To investigate activity in the limbic and paralimbic brain regions in PTSD in response to a challenge with emotionally salient generic visual images.
Design: Cross-sectional, case-control study.
Setting: Academic medical center.
Participants: Sixteen Vietnam veterans with combat-related PTSD (PTSD group), 15 combat-exposed Vietnam veterans without PTSD (combat control group), and 15 age- and sex-matched healthy controls (normal control group).
Main outcome measures: We used positron emission tomography to study regional cerebral blood flow while participants viewed complex visual pictures with negatively valenced/aversive, nonaversive ("neutral"), and blank pictures. Psychophysiologic and emotional self-report data were also recorded.
Results: All 3 groups activated the dorsal MPFC to general salient content. Controls without PTSD activated the left amygdala in response to aversive stimuli. Normal controls activated the ventral MPFC and combat-exposed non-PTSD and PTSD participants exhibited either no response or deactivation in these regions, respectively, during negative emotional experience.
Conclusions: Consistent with current functional neuroanatomic models, patients with PTSD exhibited altered neural responses in the amygdala and ventral MPFC during the processing of emotionally salient but trauma-unrelated stimuli, potentially reflecting disorder-specific changes. Activation of the amygdala and lack of ventral MPFC deactivation to negatively valenced images in combat controls may reflect compensatory changes after trauma exposure that are not associated with PTSD.
Similar articles
- Paralimbic and medial prefrontal cortical involvement in neuroendocrine responses to traumatic stimuli.
Liberzon I, King AP, Britton JC, Phan KL, Abelson JL, Taylor SF. Liberzon I, et al. Am J Psychiatry. 2007 Aug;164(8):1250-8. doi: 10.1176/appi.ajp.2007.06081367. Am J Psychiatry. 2007. PMID: 17671289 - Corticolimbic blood flow in posttraumatic stress disorder during script-driven imagery.
Britton JC, Phan KL, Taylor SF, Fig LM, Liberzon I. Britton JC, et al. Biol Psychiatry. 2005 Apr 15;57(8):832-40. doi: 10.1016/j.biopsych.2004.12.025. Biol Psychiatry. 2005. PMID: 15820703 Clinical Trial. - Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD.
Shin LM, Orr SP, Carson MA, Rauch SL, Macklin ML, Lasko NB, Peters PM, Metzger LJ, Dougherty DD, Cannistraro PA, Alpert NM, Fischman AJ, Pitman RK. Shin LM, et al. Arch Gen Psychiatry. 2004 Feb;61(2):168-76. doi: 10.1001/archpsyc.61.2.168. Arch Gen Psychiatry. 2004. PMID: 14757593 - Neural correlates of traumatic recall in posttraumatic stress disorder.
Liberzon I, Britton JC, Phan KL. Liberzon I, et al. Stress. 2003 Sep;6(3):151-6. doi: 10.1080/1025389031000136242. Stress. 2003. PMID: 13129808 Review. - Investigating the pathogenesis of posttraumatic stress disorder with neuroimaging.
Pitman RK, Shin LM, Rauch SL. Pitman RK, et al. J Clin Psychiatry. 2001;62 Suppl 17:47-54. J Clin Psychiatry. 2001. PMID: 11495097 Review.
Cited by
- Neural correlates of PTSD in women with childhood sexual abuse with and without PTSD and response to paroxetine treatment: A placebo-controlled, double-blind trial.
Bremner JD, Ortego RA, Campanella C, Nye JA, Davis LL, Fani N, Vaccarino V. Bremner JD, et al. J Affect Disord Rep. 2023 Dec;14:100615. doi: 10.1016/j.jadr.2023.100615. Epub 2023 Jun 24. J Affect Disord Rep. 2023. PMID: 38088987 Free PMC article. - Blunted diurnal interleukin-6 rhythm is associated with amygdala emotional hyporeactivity and depression: a modulating role of gene-stressor interactions.
Hakamata Y, Hori H, Mizukami S, Izawa S, Yoshida F, Moriguchi Y, Hanakawa T, Inoue Y, Tagaya H. Hakamata Y, et al. Front Psychiatry. 2023 May 30;14:1196235. doi: 10.3389/fpsyt.2023.1196235. eCollection 2023. Front Psychiatry. 2023. PMID: 37324818 Free PMC article. - Mapping structural covariance networks in children and adolescents with post-traumatic stress disorder after earthquake.
Mo X, He M, Zhou L, Liu Y, Zhu H, Huang X, Zeng G, Zhang J, Li L. Mo X, et al. Front Psychiatry. 2022 Sep 15;13:923572. doi: 10.3389/fpsyt.2022.923572. eCollection 2022. Front Psychiatry. 2022. PMID: 36186852 Free PMC article. - Non-invasive cervical vagus nerve stimulation effects on reaction time and valence image anticipation response.
Lerman I, Klaming R, Spadoni A, Baker DG, Simmons AN. Lerman I, et al. Brain Stimul. 2022 Jul-Aug;15(4):946-956. doi: 10.1016/j.brs.2022.06.006. Epub 2022 Jun 20. Brain Stimul. 2022. PMID: 35738468 Free PMC article. - Daily Optogenetic Stimulation of the Left Infralimbic Cortex Reverses Extinction Impairments in Male Rats Exposed to Single Prolonged Stress.
Canto-de-Souza L, Demetrovich PG, Plas S, Souza RR, Epperson J, Wahlstrom KL, Nunes-de-Souza RL, LaLumiere RT, Planeta CS, McIntyre CK. Canto-de-Souza L, et al. Front Behav Neurosci. 2021 Dec 20;15:780326. doi: 10.3389/fnbeh.2021.780326. eCollection 2021. Front Behav Neurosci. 2021. PMID: 34987362 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical