Genetic epidemiology of rheumatoid arthritis - PubMed (original) (raw)

Review

Genetic epidemiology of rheumatoid arthritis

Jacqueline E Oliver et al. Curr Opin Rheumatol. 2006 Mar.

Abstract

Purpose of review: This review aims to summarize articles published between October 2004 and November 2005 that have investigated the genetic epidemiology of rheumatoid arthritis.

Recent findings: The consistent replication of an association between the R620W single nucleotide polymorphism in PTPN22 and rheumatoid arthritis clearly establishes this polymorphism as an important risk factor for rheumatoid arthritis.

Summary: Genetic investigations of rheumatoid arthritis have predominantly been single nucleotide polymorphism-based candidate gene association studies searching for markers of susceptibility, severity or treatment response. Studies of the human leukocyte antigen region have refined and added to our understanding of the complex associations to polymorphisms with this locus. PTPN22 has emerged strongly as a genuine rheumatoid arthritis susceptibility gene with replications of the association to the R620W single nucleotide polymorphism. Many investigations have been conducted on the genetics of treatment response -- some 'generic' and others specific in terms of identifying genetic influences to the mode of action and metabolism of particular agents.

PubMed Disclaimer

Similar articles

• The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status.
  Lee AT, Li W, Liew A, Bombardier C, Weisman M, Massarotti EM, Kent J, Wolfe F, Begovich AB, Gregersen PK. Lee AT, et al. Genes Immun. 2005 Mar;6(2):129-33. doi: 10.1038/sj.gene.6364159. Genes Immun. 2005. PMID: 15674368
• Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.
  van Oene M, Wintle RF, Liu X, Yazdanpanah M, Gu X, Newman B, Kwan A, Johnson B, Owen J, Greer W, Mosher D, Maksymowych W, Keystone E, Rubin LA, Amos CI, Siminovitch KA. van Oene M, et al. Arthritis Rheum. 2005 Jul;52(7):1993-8. doi: 10.1002/art.21123. Arthritis Rheum. 2005. PMID: 15986374
• The association of PTPN22 with rheumatoid arthritis and juvenile idiopathic arthritis.
  Hinks A, Worthington J, Thomson W. Hinks A, et al. Rheumatology (Oxford). 2006 Apr;45(4):365-8. doi: 10.1093/rheumatology/kel005. Epub 2006 Jan 17. Rheumatology (Oxford). 2006. PMID: 16418195 Review. No abstract available.
• Association of the PTPN22 C1858T single-nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort.
  Wesoly J, van der Helm-van Mil AH, Toes RE, Chokkalingam AP, Carlton VE, Begovich AB, Huizinga TW. Wesoly J, et al. Arthritis Rheum. 2005 Sep;52(9):2948-50. doi: 10.1002/art.21294. Arthritis Rheum. 2005. PMID: 16145680 No abstract available.
• Investigating the genetic basis of susceptibility to rheumatoid arthritis.
  Worthington J. Worthington J. J Autoimmun. 2005;25 Suppl:16-20. doi: 10.1016/j.jaut.2005.09.011. Epub 2005 Oct 27. J Autoimmun. 2005. PMID: 16257177 Review.

Cited by

• Exploring epistasis in candidate genes for rheumatoid arthritis.
  Ritchie MD, Bartlett J, Bush WS, Edwards TL, Motsinger AA, Torstenson ES. Ritchie MD, et al. BMC Proc. 2007;1 Suppl 1(Suppl 1):S70. doi: 10.1186/1753-6561-1-s1-s70. Epub 2007 Dec 18. BMC Proc. 2007. PMID: 18466572 Free PMC article.
• Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects.
  Nielsen KR, Steffensen R, Boegsted M, Baech J, Lundbye-Christensen S, Hetland ML, Krintel SB, Johnsen HE, Nyegaard M, Johansen JS. Nielsen KR, et al. Arthritis Res Ther. 2011 Jun 29;13(3):R109. doi: 10.1186/ar3391. Arthritis Res Ther. 2011. PMID: 21714862 Free PMC article.
• Whole-Exome Sequencing and Analysis of the T Cell Receptor β and γ Repertoires in Rheumatoid Arthritis.
  Cho J, Kim J, Song JS, Uh Y, Lee JH, Lee HS. Cho J, et al. Diagnostics (Basel). 2024 Mar 1;14(5):529. doi: 10.3390/diagnostics14050529. Diagnostics (Basel). 2024. PMID: 38473001 Free PMC article.
• What epidemiology has told us about risk factors and aetiopathogenesis in rheumatic diseases.
  Oliver JE, Silman AJ. Oliver JE, et al. Arthritis Res Ther. 2009;11(3):223. doi: 10.1186/ar2585. Epub 2009 May 19. Arthritis Res Ther. 2009. PMID: 19490599 Free PMC article.
• Linkage analysis of anti-CCP levels as dichotomized and quantitative traits using GAW15 single-nucleotide polymorphism scan of NARAC families.
  Yang XR, Kerstann KF, Bergen AW, Goldstein AM, Goldin LR. Yang XR, et al. BMC Proc. 2007;1 Suppl 1(Suppl 1):S107. doi: 10.1186/1753-6561-1-s1-s107. Epub 2007 Dec 18. BMC Proc. 2007. PMID: 18466447 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wolters Kluwer

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Research Materials

  • NCI CPTC Antibody Characterization Program