Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2 - PubMed (original) (raw)

doi: 10.1038/ni1309. Epub 2006 Feb 5.

Affiliations

PMID: 16462739
DOI: 10.1038/ni1309

Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2

Natalya V Serbina et al. Nat Immunol. 2006 Mar.

Abstract

Monocytes recruited to tissues mediate defense against microbes or contribute to inflammatory diseases. Regulation of the number of circulating monocytes thus has implications for disease pathogenesis. However, the mechanisms controlling monocyte emigration from the bone marrow niche where they are generated remain undefined. We demonstrate here that the chemokine receptor CCR2 was required for emigration of Ly6C(hi) monocytes from bone marrow. Ccr2(-/-) mice had fewer circulating Ly6C(hi) monocytes and, after infection with Listeria monocytogenes, accumulated activated monocytes in bone marrow. In blood, Ccr2(-/-) monocytes could traffic to sites of infection, demonstrating that CCR2 is not required for migration from the circulation into tissues. Thus, CCR2-mediated signals in bone marrow determine the frequency of Ly6C(hi) monocytes in the circulation.

PubMed Disclaimer

Comment in

Release the hounds! A chemokine elicits monocytes from bone marrow.
Rollins BJ. Rollins BJ. Nat Immunol. 2006 Mar;7(3):230-2. doi: 10.1038/ni0306-230. Nat Immunol. 2006. PMID: 16482169 No abstract available.

Cited by

Immunometabolic cues recompose and reprogram the microenvironment around implanted biomaterials.
Maduka CV, Schmitter-Sánchez AD, Makela AV, Ural E, Stivers KB, Pope H, Kuhnert MM, Habeeb OM, Tundo A, Alhaj M, Kiselev A, Chen S, Donneys A, Winton WP, Stauff J, Scott PJH, Olive AJ, Hankenson KD, Narayan R, Park S, Elisseeff JH, Contag CH. Maduka CV, et al. Nat Biomed Eng. 2024 Oct 4. doi: 10.1038/s41551-024-01260-0. Online ahead of print. Nat Biomed Eng. 2024. PMID: 39367264
Complex Pathophysiology of Acute Kidney Injury (AKI) in Aging: Epigenetic Regulation, Matrix Remodeling, and the Healing Effects of H2S.
Gupta S, Mandal S, Banerjee K, Almarshood H, Pushpakumar SB, Sen U. Gupta S, et al. Biomolecules. 2024 Sep 17;14(9):1165. doi: 10.3390/biom14091165. Biomolecules. 2024. PMID: 39334931 Free PMC article. Review.
Decreased Systemic Monocyte Colony Protein-1 (MCP-1) Levels and Reduced sCD14 Levels in Curcumin-Treated Patients with Moderate Anxiety: A Pilot Study.
Merino JJ, Parmigiani-Cabaña JM, Parmigiani-Izquierdo JM, Fernández-García R, Cabaña-Muñoz ME. Merino JJ, et al. Antioxidants (Basel). 2024 Aug 29;13(9):1052. doi: 10.3390/antiox13091052. Antioxidants (Basel). 2024. PMID: 39334711 Free PMC article.
Loss of embryonically-derived Kupffer cells during hypercholesterolemia accelerates atherosclerosis development.
Fima R, Dussaud S, Benbida C, Blanchet M, Lanthiez F, Poupel L, Brambilla C, Gélineau A, Dessena M, Blanc M, Lerévérend C, Moreau M, Boissonnas A, Gautier EL, Huby T. Fima R, et al. Nat Commun. 2024 Sep 27;15(1):8341. doi: 10.1038/s41467-024-52735-2. Nat Commun. 2024. PMID: 39333539 Free PMC article.
Resolvin D2/GPR18 signaling enhances monocytic myeloid-derived suppressor cell function to mitigate abdominal aortic aneurysm formation.
Bellotti P, Ladd Z, Leroy V, Su G, Sharma S, Hartman JB, Krebs J, Viscardi C, Maile R, Moldawer LL, Efron PA, Sharma AK, Upchurch GR Jr. Bellotti P, et al. FASEB J. 2024 Sep 30;38(18):e70067. doi: 10.1096/fj.202400414RRR. FASEB J. 2024. PMID: 39320982

Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2 - PubMed (original) (raw)