Assessment of the microRNA system in salt-sensitive hypertension - PubMed (original) (raw)

. 2005 Oct;28(10):819-26.

doi: 10.1291/hypres.28.819.

Affiliations

• PMID: 16471176
• DOI: 10.1291/hypres.28.819

Assessment of the microRNA system in salt-sensitive hypertension

Hiroaki Naraba et al. Hypertens Res. 2005 Oct.

Abstract

Most animal microRNAs are imperfectly complementary to their mRNA targets and inhibit protein synthesis through an unknown mechanism. MicroRNAs have been reported to play important roles in a number of biological processes. We assessed the microRNA system in Dahl salt-sensitive rats in order to investigate possible roles of microRNA in salt-sensitive hypertension. We constructed microRNA libraries from the kidneys of Dahl salt-sensitive and Lewis rats taking normal or high-salt diets (4 groups), and identified 91 previously reported and 12 new microRNAs expressed in the kidney. We then used Northern blotting to assess the expression levels of 118 microRNAs in the kidneys and heart ventricles. No significant differences in microRNA expression profiles were observed among the 4 groups. Thus, the microRNA system seemed to be unlikely to contribute to salt-sensitive hypertension in Dahl salt-sensitive rats.

PubMed Disclaimer

Similar articles

• The monocyte chemotactic protein-1 gene may contribute to hypertension in Dahl salt-sensitive rats.
  Yasui N, Kajimoto K, Sumiya T, Okuda T, Iwai N. Yasui N, et al. Hypertens Res. 2007 Feb;30(2):185-93. doi: 10.1291/hypres.30.185. Hypertens Res. 2007. PMID: 17460389
• Assessment of mitochondrial DNA polymorphisms in salt-sensitive hypertension in Dahl salt-sensitive rats.
  Chen CS, Hiura Y, Shen CS, Iwai N. Chen CS, et al. Hypertens Res. 2008 Jan;31(1):107-15. doi: 10.1291/hypres.31.107. Hypertens Res. 2008. PMID: 18360025
• Aberrant ENaC activation in Dahl salt-sensitive rats.
  Kakizoe Y, Kitamura K, Ko T, Wakida N, Maekawa A, Miyoshi T, Shiraishi N, Adachi M, Zhang Z, Masilamani S, Tomita K. Kakizoe Y, et al. J Hypertens. 2009 Aug;27(8):1679-89. doi: 10.1097/HJH.0b013e32832c7d23. J Hypertens. 2009. PMID: 19458538
• Riboregulators in kidney development and function.
  Karolina DS, Wintour EM, Bertram J, Jeyaseelan K. Karolina DS, et al. Biochimie. 2010 Mar;92(3):217-25. doi: 10.1016/j.biochi.2009.12.008. Epub 2009 Dec 31. Biochimie. 2010. PMID: 20045037 Review.
• The art of microRNA research.
  van Rooij E. van Rooij E. Circ Res. 2011 Jan 21;108(2):219-34. doi: 10.1161/CIRCRESAHA.110.227496. Circ Res. 2011. PMID: 21252150 Review.

Cited by

• Mechanisms and therapeutic potential of microRNAs in hypertension.
  Shi L, Liao J, Liu B, Zeng F, Zhang L. Shi L, et al. Drug Discov Today. 2015 Oct;20(10):1188-204. doi: 10.1016/j.drudis.2015.05.007. Epub 2015 May 21. Drug Discov Today. 2015. PMID: 26004493 Free PMC article. Review.
• Renal medullary microRNAs in Dahl salt-sensitive rats: miR-29b regulates several collagens and related genes.
  Liu Y, Taylor NE, Lu L, Usa K, Cowley AW Jr, Ferreri NR, Yeo NC, Liang M. Liu Y, et al. Hypertension. 2010 Apr;55(4):974-82. doi: 10.1161/HYPERTENSIONAHA.109.144428. Epub 2010 Mar 1. Hypertension. 2010. PMID: 20194304 Free PMC article.
• MicroRNAs miR-124 and miR-135a are potential regulators of the mineralocorticoid receptor gene (NR3C2) expression.
  Sõber S, Laan M, Annilo T. Sõber S, et al. Biochem Biophys Res Commun. 2010 Jan 1;391(1):727-32. doi: 10.1016/j.bbrc.2009.11.128. Epub 2009 Nov 26. Biochem Biophys Res Commun. 2010. PMID: 19944075 Free PMC article.
• Panel miRNAs are potential diagnostic markers for chronic kidney diseases: a systematic review and meta-analysis.
  Garmaa G, Nagy R, Kói T, To UND, Gergő D, Kleiner D, Csupor D, Hegyi P, Kökény G. Garmaa G, et al. BMC Nephrol. 2024 Aug 13;25(1):261. doi: 10.1186/s12882-024-03702-y. BMC Nephrol. 2024. PMID: 39138396 Free PMC article.
• Cardiac insulin resistance and microRNA modulators.
  Pulakat L, Aroor AR, Gul R, Sowers JR. Pulakat L, et al. Exp Diabetes Res. 2012;2012:654904. doi: 10.1155/2012/654904. Epub 2011 Jul 31. Exp Diabetes Res. 2012. PMID: 21977024 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Medical

  • MedlinePlus Health Information