Nuclear actin: to polymerize or not to polymerize - PubMed (original) (raw)

Review

Nuclear actin: to polymerize or not to polymerize

Wilma A Hofmann et al. J Cell Biol. 2006.

Abstract

The form and function of actin in the nucleus have been enigmatic for over 30 years. Recently actin has been assigned numerous functional roles in the nucleus, but its form remains a mystery. The intricate relationship between actin form and function in the cytoplasm implies that understanding the structural properties of nuclear actin is elementary to fully understanding its function. In this issue, McDonald et al. (p. 541) use fluorescence recovery after photobleaching (FRAP) to tackle the question of whether nuclear actin exists as monomers or polymers.

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• Nucleoplasmic beta-actin exists in a dynamic equilibrium between low-mobility polymeric species and rapidly diffusing populations.
  McDonald D, Carrero G, Andrin C, de Vries G, Hendzel MJ. McDonald D, et al. J Cell Biol. 2006 Feb 13;172(4):541-52. doi: 10.1083/jcb.200507101. J Cell Biol. 2006. PMID: 16476775 Free PMC article.

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