E-cadherin in gastric cancer - PubMed (original) (raw)

Review

E-cadherin in gastric cancer

Annie On On Chan. World J Gastroenterol. 2006.

Abstract

Cadherin is an adhesion molecule and a superfamily of calcium-mediated membrane glycoproteins. E-cadherin is the prototype of the class E-cadherin that links to catenins to form the cytoskeleton. Recent evidence has shown that E-cadherin not only acts as an adhesive, but also plays important roles in growth development and carcinogenesis. It has been recently viewed as an invasion as well as a growth suppressor gene. This review summarizes the recent discoveries on E-cadherin and its role in gastric cancer. In particular, our work on E-cadherin in gastric cancer, including its relation with Helicobacter pylori and clinical applications, are described in detail.

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Figures

Figure 1

Illustrated interaction between the cadherin–catenin complex and the APC protein. (A) In the absence of Wnt-1 and the presence of glycogen synthase kinase (GSK), β-catenin (β-cat) is stabilized and bound to cadherin or APC protein. Cadherin acts as a negative regulator of β-catenin by regulating the amount of free β-catenin. The free cytoplasmic β-catenin is degraded. (B) In the presence of Wnt-1, GSK is antagonized and mutant APC or tyrosine phosphorylated β-catenin cannot bind to each other, cytosolic free β-catenin concentrations rise, which leads to down-stream cell signalling and may be involved in carcinogenesis.

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