RETRACTED: Cdx2 gene expression and trophectoderm lineage specification in mouse embryos - PubMed (original) (raw)

. 2006 Feb 17;311(5763):992-6.

doi: 10.1126/science.1120925.

Affiliations

• PMID: 16484492
• DOI: 10.1126/science.1120925

RETRACTED: Cdx2 gene expression and trophectoderm lineage specification in mouse embryos

Kaushik Deb et al. Science. 2006.

Retraction in

• Retraction.
  Roberts RM, Sivaguru M, Yong HY. Roberts RM, et al. Science. 2007 Jul 27;317(5837):450. doi: 10.1126/science.317.5837.450b. Science. 2007. PMID: 17656701 No abstract available.

Expression of concern in

• Editorial expression of concern.
  Kennedy D. Kennedy D. Science. 2006 Oct 27;314(5799):592. doi: 10.1126/science.314.5799.592b. Science. 2006. PMID: 17068242 No abstract available.

Abstract

Controversy exists as to whether individual blastomeres from two-cell-stage mouse embryos have identical developmental properties and fate. We show that the transcription factor Cdx2 is expressed in the nuclei of cells derived from the late-dividing but not the first-dividing blastomere of two-cell embryos and, by lineage tracing and RNA interference knock-down experiments, that this lagging cell is the precursor of trophectoderm. Cdx2 mRNA is localized toward the vegetal pole of oocytes, reorients after fertilization, and becomes concentrated in the late-dividing, two-cell-stage blastomere. The asymmetrical distribution of Cdx2 gene products in the oocyte and embryo defines the lineage to trophectoderm.

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Comment in

• Developmental biology. Fraud investigation clouds paper on early cell fate.
  Vogel G. Vogel G. Science. 2006 Dec 1;314(5804):1367-9. doi: 10.1126/science.314.5804.1367. Science. 2006. PMID: 17138872 No abstract available.
• Findings of research misconduct.
  [No authors listed] [No authors listed] NIH Guide Grants Contracts. 2014 Dec 5:NOT-OD-15-034. NIH Guide Grants Contracts. 2014. PMID: 25528785 Free PMC article. No abstract available.
• Findings of Misconduct in Science.
  [No authors listed] [No authors listed] Fed Regist. 2014 Dec 9;79(236):73077. Fed Regist. 2014. PMID: 27737251 Free PMC article. No abstract available.

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