Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number - PubMed (original) (raw)
. 2006 Feb 17;311(5763):1008-12.
doi: 10.1126/science.1122511.
Affiliations
- PMID: 16484497
- DOI: 10.1126/science.1122511
Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number
Steven W Flavell et al. Science. 2006.
Abstract
In the mammalian nervous system, neuronal activity regulates the strength and number of synapses formed. The genetic program that coordinates this process is poorly understood. We show that myocyte enhancer factor 2 (MEF2) transcription factors suppressed excitatory synapse number in a neuronal activity- and calcineurin-dependent manner as hippocampal neurons formed synapses. In response to increased neuronal activity, calcium influx into neurons induced the activation of the calcium/calmodulin-regulated phosphatase calcineurin, which dephosphorylated and activated MEF2. When activated, MEF2 promoted the transcription of a set of genes, including arc and synGAP, that restrict synapse number. These findings define an activity-dependent transcriptional program that may control synapse number during development.
Comment in
- Neuroscience. SUMO wrestles the synapse.
Beg AA, Scheiffele P. Beg AA, et al. Science. 2006 Feb 17;311(5763):962-3. doi: 10.1126/science.1124541. Science. 2006. PMID: 16484483 No abstract available.
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