Generation of an adult smooth muscle cell-targeted Cre recombinase mouse model - PubMed (original) (raw)

doi: 10.1161/01.ATV.0000202661.61837.93.

Wei Zhong, Taixing Cui, Maozhou Yang, Xing Hu, Kefeng Xu, Changqing Xie, Changyong Xue, Gary H Gibbons, Chengyu Liu, Li Li, Yuqing E Chen

Generation of an adult smooth muscle cell-targeted Cre recombinase mouse model

Jifeng Zhang et al. Arterioscler Thromb Vasc Biol. 2006 Mar.

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Figure

Characterization of SM22α-CreKI mice. A, Cellular expression of Cre-recombinase in SM22α-CreKI mice. X-Gal–stained organs and sections were prepared from 8-week-old SM22α-CreKI and Gt(Rosa)26Sor double heterozygous mice or wild-type littermates. X-Gal staining shows that Cre-recombinase is expressed in SMCs and cardiomyocytes in adult. B, Western blot analyses show GFP protein expressed in the aorta and the heart of 8-week-old SM22α-CreKI and Gtrosa26 double heterozygous or double homozygous mice and the control wild-type littermates. GFP protein is the positive control. Wt indicates wild-type; A, aorta; B, brain; H, heart; M, skeletal muscle. Bar = 100 µm.

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