The role of IL-10 in crossregulation of TH1 and TH2 responses - PubMed (original) (raw)
Review
The role of IL-10 in crossregulation of TH1 and TH2 responses
T R Mosmann et al. Immunol Today. 1991 Mar.
Abstract
The identification of helper T (TH)-cell subsets has greatly improved understanding of the regulation of immune effector functions. In addition to controlling humoral and delayed-type hypersensitivity responses, these subsets crossregulate by secreting mutually inhibitory cytokines. In this review, Tim Mosmann and Kevin Moore examine these phenomena and in particular the role of interleukin 10, a cytokine secreted by TH2 cells that inhibits TH1-cell function.
Similar articles
- Type 1 T helper and type 2 T helper cells: functions, regulation and role in protection and disease.
Romagnani S. Romagnani S. Int J Clin Lab Res. 1991;21(2):152-8. doi: 10.1007/BF02591635. Int J Clin Lab Res. 1991. PMID: 1687725 Review. - Cytokine secretion patterns and cross-regulation of T cell subsets.
Mosmann TR. Mosmann TR. Immunol Res. 1991;10(3-4):183-8. doi: 10.1007/BF02919690. Immunol Res. 1991. PMID: 1659603 Review. No abstract available. - Th1/Th2 cross regulation.
Fishman MA, Perelson AS. Fishman MA, et al. J Theor Biol. 1994 Sep 7;170(1):25-56. doi: 10.1006/jtbi.1994.1166. J Theor Biol. 1994. PMID: 7967633 - Functional diversity of T lymphocytes due to secretion of different cytokine patterns.
Street NE, Mosmann TR. Street NE, et al. FASEB J. 1991 Feb;5(2):171-7. doi: 10.1096/fasebj.5.2.1825981. FASEB J. 1991. PMID: 1825981 Review. - T follicular helper and TH2 cells in allergic responses.
Kubo M. Kubo M. Allergol Int. 2017 Jul;66(3):377-381. doi: 10.1016/j.alit.2017.04.006. Epub 2017 May 9. Allergol Int. 2017. PMID: 28499720 Review.
Cited by
- Hypothetical proteins of chicken-isolated Limosilactobacillus reuteri subjected to in silico analyses induce IL-2 and IL-10.
Adejumo IO. Adejumo IO. Genes Nutr. 2024 Oct 19;19(1):21. doi: 10.1186/s12263-024-00755-4. Genes Nutr. 2024. PMID: 39425027 - Chimeric antigen receptor T cell therapy for autoimmune disease.
Chung JB, Brudno JN, Borie D, Kochenderfer JN. Chung JB, et al. Nat Rev Immunol. 2024 Jun 3. doi: 10.1038/s41577-024-01035-3. Online ahead of print. Nat Rev Immunol. 2024. PMID: 38831163 Review. - Regulation of Treg cells by cytokine signaling and co-stimulatory molecules.
Zong Y, Deng K, Chong WP. Zong Y, et al. Front Immunol. 2024 May 13;15:1387975. doi: 10.3389/fimmu.2024.1387975. eCollection 2024. Front Immunol. 2024. PMID: 38807592 Free PMC article. Review. - T cells and their products in diabetic kidney disease.
Liu Y, Lv Y, Zhang T, Huang T, Lang Y, Sheng Q, Liu Y, Kong Z, Gao Y, Lu S, Yang M, Luan Y, Wang X, Lv Z. Liu Y, et al. Front Immunol. 2023 Jan 26;14:1084448. doi: 10.3389/fimmu.2023.1084448. eCollection 2023. Front Immunol. 2023. PMID: 36776877 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources