ILK, PINCH and parvin: the tIPP of integrin signalling - PubMed (original) (raw)
Review
doi: 10.1038/nrm1789.
Affiliations
- PMID: 16493410
- DOI: 10.1038/nrm1789
Review
ILK, PINCH and parvin: the tIPP of integrin signalling
Kyle R Legate et al. Nat Rev Mol Cell Biol. 2006 Jan.
Abstract
The ternary complex of integrin-linked kinase (ILK), PINCH and parvin functions as a signalling platform for integrins by interfacing with the actin cytoskeleton and many diverse signalling pathways. All these proteins have synergistic functions at focal adhesions, but recent work has indicated that these proteins might also have separate roles within a cell. They function as regulators of gene transcription or cell-cell adhesion.
Similar articles
- Formation and phosphorylation of the PINCH-1-integrin linked kinase-alpha-parvin complex are important for regulation of renal glomerular podocyte adhesion, architecture, and survival.
Yang Y, Guo L, Blattner SM, Mundel P, Kretzler M, Wu C. Yang Y, et al. J Am Soc Nephrol. 2005 Jul;16(7):1966-76. doi: 10.1681/ASN.2004121112. Epub 2005 May 4. J Am Soc Nephrol. 2005. PMID: 15872073 - How integrins control mammary epithelial differentiation: a possible role for the ILK-PINCH-Parvin complex.
Rooney N, Streuli CH. Rooney N, et al. FEBS Lett. 2011 Jun 6;585(11):1663-72. doi: 10.1016/j.febslet.2011.05.014. Epub 2011 May 10. FEBS Lett. 2011. PMID: 21570968 Review. - The integrin-actin connection, an eternal love affair.
Brakebusch C, Fässler R. Brakebusch C, et al. EMBO J. 2003 May 15;22(10):2324-33. doi: 10.1093/emboj/cdg245. EMBO J. 2003. PMID: 12743027 Free PMC article. Review. - Mapping the integrin-linked kinase interactome using SILAC.
Dobreva I, Fielding A, Foster LJ, Dedhar S. Dobreva I, et al. J Proteome Res. 2008 Apr;7(4):1740-9. doi: 10.1021/pr700852r. Epub 2008 Mar 10. J Proteome Res. 2008. PMID: 18327965 - Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction.
Yamaji S, Suzuki A, Kanamori H, Mishima W, Yoshimi R, Takasaki H, Takabayashi M, Fujimaki K, Fujisawa S, Ohno S, Ishigatsubo Y. Yamaji S, et al. J Cell Biol. 2004 May 24;165(4):539-51. doi: 10.1083/jcb.200308141. J Cell Biol. 2004. PMID: 15159419 Free PMC article.
Cited by
- Integrin αVβ3 mediates porcine deltacoronavirus infection and inflammatory response through activation of the FAK-PI3K-AKT-nf-κB signalling pathway.
Jin X, Wu X, Li Z, Hu Y, Xia L, Zu S, Zhang G, Hu H. Jin X, et al. Virulence. 2024 Dec;15(1):2407847. doi: 10.1080/21505594.2024.2407847. Epub 2024 Oct 5. Virulence. 2024. PMID: 39368071 Free PMC article. - α-Parvin Expression in Breast Cancer Tissues: Correlation with Clinical Parameters and Prognostic Significance.
Takeda M, Ito H, Kitahata K, Sato S, Nishide A, Gamo K, Managi S, Tezuka T, Yoshizawa A, Kim M. Takeda M, et al. Cells. 2024 Sep 19;13(18):1572. doi: 10.3390/cells13181572. Cells. 2024. PMID: 39329755 Free PMC article. - Integrin-linked kinase mRNA expression in circulating mononuclear cells as a biomarker of kidney and vascular damage in experimental chronic kidney disease.
Campillo S, Gutiérrez-Calabrés E, García-Miranda S, Griera M, Fernández Rodríguez L, de Frutos S, Rodríguez-Puyol D, Calleros L. Campillo S, et al. Cell Commun Signal. 2024 May 11;22(1):264. doi: 10.1186/s12964-024-01646-2. Cell Commun Signal. 2024. PMID: 38734696 Free PMC article. - Global research trends and emerging opportunities for integrin adhesion complexes in cardiac repair: a scientometric analysis.
Lv J, Fu Z, Zheng H, Song Q. Lv J, et al. Front Cardiovasc Med. 2024 Apr 18;11:1308763. doi: 10.3389/fcvm.2024.1308763. eCollection 2024. Front Cardiovasc Med. 2024. PMID: 38699584 Free PMC article. - Neutrophil extracellular traps promote proliferation of pulmonary smooth muscle cells mediated by CCDC25 in pulmonary arterial hypertension.
Sun H, Du Z, Zhang X, Gao S, Ji Z, Luo G, Pan S. Sun H, et al. Respir Res. 2024 Apr 25;25(1):183. doi: 10.1186/s12931-024-02813-2. Respir Res. 2024. PMID: 38664728 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources