Combinatorial roles of nuclear receptors in inflammation and immunity - PubMed (original) (raw)
Review
doi: 10.1038/nri1748.
Affiliations
- PMID: 16493426
- DOI: 10.1038/nri1748
Review
Combinatorial roles of nuclear receptors in inflammation and immunity
Christopher K Glass et al. Nat Rev Immunol. 2006 Jan.
Abstract
Members of the nuclear-receptor superfamily have well-documented regulatory effects on inflammatory processes. Recent work has highlighted the roles of peroxisome-proliferator-activated receptors (PPARs) and liver X receptors (LXRs) in controlling metabolic and inflammatory programmes of gene expression in macrophages and lymphocytes. Here, we describe recent studies that extend our understanding of how these nuclear receptors, through their interactions with transcription factors and other cell-signalling systems, have important regulatory roles in innate and adaptive immunity. We suggest that by using receptor-specific mechanisms, PPARs and LXRs function in a combinatorial manner with the glucocorticoid receptor to integrate local and systemic responses to inflammation.
Similar articles
- Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors.
Hong C, Tontonoz P. Hong C, et al. Curr Opin Genet Dev. 2008 Oct;18(5):461-7. doi: 10.1016/j.gde.2008.07.016. Epub 2008 Sep 7. Curr Opin Genet Dev. 2008. PMID: 18782619 Free PMC article. Review. - Gaining weight: the Keystone Symposium on PPAR and LXR.
Lehrke M, Pascual G, Glass CK, Lazar MA. Lehrke M, et al. Genes Dev. 2005 Aug 1;19(15):1737-42. doi: 10.1101/gad.1341005. Genes Dev. 2005. PMID: 16077002 Free PMC article. - Integration of metabolism and inflammation by lipid-activated nuclear receptors.
Bensinger SJ, Tontonoz P. Bensinger SJ, et al. Nature. 2008 Jul 24;454(7203):470-7. doi: 10.1038/nature07202. Nature. 2008. PMID: 18650918 Review. - PPARs and LXRs: atherosclerosis goes nuclear.
Barish GD, Evans RM. Barish GD, et al. Trends Endocrinol Metab. 2004 May-Jun;15(4):158-65. doi: 10.1016/j.tem.2004.03.003. Trends Endocrinol Metab. 2004. PMID: 15109614 Review. - Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation.
Castrillo A, Tontonoz P. Castrillo A, et al. Annu Rev Cell Dev Biol. 2004;20:455-80. doi: 10.1146/annurev.cellbio.20.012103.134432. Annu Rev Cell Dev Biol. 2004. PMID: 15473848 Review.
Cited by
- Surgery and stress promote cancer metastasis: new outlooks on perioperative mediating mechanisms and immune involvement.
Neeman E, Ben-Eliyahu S. Neeman E, et al. Brain Behav Immun. 2013 Mar;30 Suppl(Suppl):S32-40. doi: 10.1016/j.bbi.2012.03.006. Epub 2012 Apr 4. Brain Behav Immun. 2013. PMID: 22504092 Free PMC article. Review. - Microbial-immune cross-talk and regulation of the immune system.
Cahenzli J, Balmer ML, McCoy KD. Cahenzli J, et al. Immunology. 2013 Jan;138(1):12-22. doi: 10.1111/j.1365-2567.2012.03624.x. Immunology. 2013. PMID: 22804726 Free PMC article. Review. - Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice.
Leuenberger N, Pradervand S, Wahli W. Leuenberger N, et al. J Clin Invest. 2009 Oct;119(10):3138-48. doi: 10.1172/JCI39019. J Clin Invest. 2009. PMID: 19729835 Free PMC article. - The human tissue-biomaterial interface: a role for PPARγ-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype.
Bullers SJ, Baker SC, Ingham E, Southgate J. Bullers SJ, et al. Tissue Eng Part A. 2014 Sep;20(17-18):2390-401. doi: 10.1089/ten.TEA.2013.0628. Epub 2014 May 20. Tissue Eng Part A. 2014. PMID: 24548290 Free PMC article. - The key genes, phosphoproteins, processes, and pathways affected by efavirenz-activated CYP46A1 in the amyloid-decreasing paradigm of efavirenz treatment.
Petrov AM, Mast N, Li Y, Pikuleva IA. Petrov AM, et al. FASEB J. 2019 Aug;33(8):8782-8798. doi: 10.1096/fj.201900092R. Epub 2019 May 7. FASEB J. 2019. PMID: 31063705 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources