Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level - PubMed (original) (raw)
Review
. 1991 Jul 22;285(2):199-212.
doi: 10.1016/0014-5793(91)80803-b.
Affiliations
- PMID: 1649771
- DOI: 10.1016/0014-5793(91)80803-b
Free article
Review
Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level
W Fiers. FEBS Lett. 1991.
Free article
Abstract
TNF was originally characterized as an antitumor agent and a factor cytotoxic for many malignant cells. It is now clear that it plays an important role in the defense against viral, bacterial and parasitic infections, - and in (auto-)immune responses. Natural induction of TNF is protective, but its overproduction may be detrimental and even lethal to the host. The structure of TNF and its interaction with the two types of cellular receptor are becoming better understood. TNF elicits a variety of events in different cell types. It subverts the electron transport system or the mitochondria into production of oxygen radicals, which can kill the (malignant) cells when these do not contain or produce protective enzymes. Furthermore, TNF induces a set of genes and at least part of this transcriptional activation is mediated by NF kappa B. The prospects of TNF as an antitumor drug can be improved on the one hand by agents such as LI+, which synergizes, and on the other hand by inhibitors of the systemic toxicity which do not interfere with the antitumor efficacy. Also, in tumor-bearing animals which have been rendered tolerant by administration of small doses of TNF, an effective and complete elimination of the tumors can be obtained by the combined action of TNF plus interferon.
Similar articles
- The molecular action of tumor necrosis factor-alpha.
Camussi G, Albano E, Tetta C, Bussolino F. Camussi G, et al. Eur J Biochem. 1991 Nov 15;202(1):3-14. doi: 10.1111/j.1432-1033.1991.tb16337.x. Eur J Biochem. 1991. PMID: 1657606 Review. - Tumor necrosis factor alpha: a multifaceted peptide hormone.
Rosenblum MG, Donato NJ. Rosenblum MG, et al. Crit Rev Immunol. 1989;9(1):21-44. Crit Rev Immunol. 1989. PMID: 2539946 Review. - [Cytokines and antagonists in septic shock].
Girardin E, Dayer JM. Girardin E, et al. Schweiz Med Wochenschr. 1993 Mar 20;123(11):480-91. Schweiz Med Wochenschr. 1993. PMID: 8386392 Review. French. - [TNF: antitumoral agent at the border lines of immunity and inflammation].
Branellec D, Chouaib S. Branellec D, et al. Pathol Biol (Paris). 1991 Mar;39(3):230-9. Pathol Biol (Paris). 1991. PMID: 1646993 Review. French.
Cited by
- In Vitro Profiling of Commonly Used Post-transplant Immunosuppressants Reveals Distinct Impact on Antiviral T-cell Immunity Towards CMV.
Krueger MB, Bonifacius A, Dragon AC, Santamorena MM, Nashan B, Taubert R, Kalinke U, Maecker-Kolhoff B, Blasczyk R, Eiz-Vesper B. Krueger MB, et al. Transpl Int. 2024 Apr 9;37:12720. doi: 10.3389/ti.2024.12720. eCollection 2024. Transpl Int. 2024. PMID: 38655204 Free PMC article. - Safety, Efficacy, and Biological Data of T-Cell-Enabling Oncolytic Adenovirus TILT-123 in Advanced Solid Cancers from the TUNIMO Monotherapy Phase I Trial.
Pakola SA, Peltola KJ, Clubb JHA, Jirovec E, Haybout L, Kudling TV, Alanko T, Korpisaari R, Juteau S, Jaakkola M, Sormunen J, Kemppainen J, Hemmes A, Pellinen T, van der Heijden M, Quixabeira DCA, Kistler C, Sorsa S, Havunen R, Santos JM, Cervera-Carrascon V, Hemminki A. Pakola SA, et al. Clin Cancer Res. 2024 Sep 3;30(17):3715-3725. doi: 10.1158/1078-0432.CCR-23-3874. Clin Cancer Res. 2024. PMID: 38546220 Free PMC article. Clinical Trial. - Atretic preovulatory follicles could be precursors of ovarian lutein cysts in the pig.
Ziecik AJ, Likszo P, Klos J, Gromadzka-Hliwa K, Knapczyk-Stwora K, Peltoniemi O, Gajewski Z, Kaczmarek MM. Ziecik AJ, et al. Sci Rep. 2023 May 12;13(1):7758. doi: 10.1038/s41598-023-34563-4. Sci Rep. 2023. PMID: 37173342 Free PMC article. - Synthesis of bioactive (1→6)-β-glucose branched poly-amido-saccharides that stimulate and induce M1 polarization in macrophages.
Xiao R, Zeng J, Bressler EM, Lu W, Grinstaff MW. Xiao R, et al. Nat Commun. 2022 Aug 9;13(1):4661. doi: 10.1038/s41467-022-32346-5. Nat Commun. 2022. PMID: 35945224 Free PMC article. - Tumor necrosis factor alpha delivers exogenous inflammation-related microRNAs to recipient cells with functional targeting capabilities.
Zhao Y, Zhang T, Shen X, Huang A, Li H, Wang L, Liu X, Wang X, Song X, Wang S, Dong J, Shao N. Zhao Y, et al. Mol Ther. 2022 Sep 7;30(9):3052-3065. doi: 10.1016/j.ymthe.2022.06.017. Epub 2022 Jul 5. Mol Ther. 2022. PMID: 35791880 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources