Neutrophils and immunity: challenges and opportunities - PubMed (original) (raw)
Review
doi: 10.1038/nri1785.
Affiliations
- PMID: 16498448
- DOI: 10.1038/nri1785
Review
Neutrophils and immunity: challenges and opportunities
Carl Nathan. Nat Rev Immunol. 2006 Mar.
Abstract
Scientists who study neutrophils often have backgrounds in cell biology, biochemistry, haematology, rheumatology or infectious disease. Paradoxically, immunologists seem to have a harder time incorporating these host-defence cells into the framework of their discipline. The recent literature discussed here indicates that it is appropriate for immunologists to take as much interest in neutrophils as in their lymphohaematopoietic cousins with smooth nuclei. Neutrophils inform and shape immune responses, contribute to the repair of tissue as well as its breakdown, use killing mechanisms that enrich our concepts of specificity, and offer exciting opportunities for the treatment of neoplastic, autoinflammatory and autoimmune disorders.
Similar articles
- Understanding the role of immune regulation in wound healing.
Park JE, Barbul A. Park JE, et al. Am J Surg. 2004 May;187(5A):11S-16S. doi: 10.1016/S0002-9610(03)00296-4. Am J Surg. 2004. PMID: 15147986 Review. - A sheep in wolf's clothes: can neutrophils direct the immune response?
Whale TA, Griebel PJ. Whale TA, et al. Vet J. 2009 May;180(2):169-77. doi: 10.1016/j.tvjl.2007.12.030. Epub 2008 Mar 4. Vet J. 2009. PMID: 18296086 Review. - The neutrophil in chronic obstructive pulmonary disease.
Quint JK, Wedzicha JA. Quint JK, et al. J Allergy Clin Immunol. 2007 May;119(5):1065-71. doi: 10.1016/j.jaci.2006.12.640. Epub 2007 Jan 30. J Allergy Clin Immunol. 2007. PMID: 17270263 Review. - Mast cells: multifaceted immune cells with diverse roles in health and disease.
Rao KN, Brown MA. Rao KN, et al. Ann N Y Acad Sci. 2008 Nov;1143:83-104. doi: 10.1196/annals.1443.023. Ann N Y Acad Sci. 2008. PMID: 19076346 Review. - Cell intrinsic mechanisms of T-cell inhibition and application to cancer therapy.
Peggs KS, Quezada SA, Allison JP. Peggs KS, et al. Immunol Rev. 2008 Aug;224:141-65. doi: 10.1111/j.1600-065X.2008.00649.x. Immunol Rev. 2008. PMID: 18759925 Review.
Cited by
- Blockade of CXCR2 suppresses proinflammatory activities of neutrophils in ulcerative colitis.
Zhu F, He H, Fan L, Ma C, Xu Z, Xue Y, Wang Y, Zhang C, Zhou G. Zhu F, et al. Am J Transl Res. 2020 Sep 15;12(9):5237-5251. eCollection 2020. Am J Transl Res. 2020. PMID: 33042416 Free PMC article. - Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis.
Cui C, Chakraborty K, Tang XA, Zhou G, Schoenfelt KQ, Becker KM, Hoffman A, Chang YF, Blank A, Reardon CA, Kenny HA, Vaisar T, Lengyel E, Greene G, Becker L. Cui C, et al. Cell. 2021 Jun 10;184(12):3163-3177.e21. doi: 10.1016/j.cell.2021.04.016. Epub 2021 May 7. Cell. 2021. PMID: 33964209 Free PMC article. - Toxoplasma gondii triggers release of human and mouse neutrophil extracellular traps.
Abi Abdallah DS, Lin C, Ball CJ, King MR, Duhamel GE, Denkers EY. Abi Abdallah DS, et al. Infect Immun. 2012 Feb;80(2):768-77. doi: 10.1128/IAI.05730-11. Epub 2011 Nov 21. Infect Immun. 2012. PMID: 22104111 Free PMC article. - A predictive model of bowel resection for incarcerated inguinal hernia based on the systemic immune-inflammation index.
Chen L, Chen L, Wang YY, Zhang LX, Xia XG. Chen L, et al. Front Surg. 2022 Sep 23;9:990481. doi: 10.3389/fsurg.2022.990481. eCollection 2022. Front Surg. 2022. PMID: 36211270 Free PMC article. - Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis.
Griseri T, Arnold IC, Pearson C, Krausgruber T, Schiering C, Franchini F, Schulthess J, McKenzie BS, Crocker PR, Powrie F. Griseri T, et al. Immunity. 2015 Jul 21;43(1):187-99. doi: 10.1016/j.immuni.2015.07.008. Immunity. 2015. PMID: 26200014 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources