Opisthorchis viverrini infestation and endogenous nitrosamines as risk factors for cholangiocarcinoma in Thailand - PubMed (original) (raw)

Comparative Study

. 1991 Jul 30;48(6):821-5.

doi: 10.1002/ijc.2910480606.

Affiliations

• PMID: 1650329
• DOI: 10.1002/ijc.2910480606

Comparative Study

Opisthorchis viverrini infestation and endogenous nitrosamines as risk factors for cholangiocarcinoma in Thailand

P Srivatanakul et al. Int J Cancer. 1991.

Abstract

Cholangiocarcinoma (CCA) is one of the most common cancers in north-east Thailand and has been associated with infestation by the liver fluke Opisthorchis viverrini (OV). Two samples of 12-hr overnight urine (after dosing with proline and ascorbic acid or proline alone) were collected from 20 inhabitants from each of 5 contrasting incidence areas for CCA. The incidence of CCA was not correlated with either the amount of NPRO or other nitrosamino acids, endogenous nitrosation potential (difference in NPRO levels between proline dose and proline and ascorbic dose), or nitrate level. However, when urinary levels of nitrosamino acids were compared in subjects living in high-risk areas, subjects who were positive for OV antibody excreted significantly more (p less than 0.01) NPRO (12.3 +/- 18.7 micrograms/12 hr) after proline ingestion than those who were negative (3.5 +/- 3.2 micrograms/12 hr). After ingestion of ascorbic acid, the NPRO levels in the positive subjects were significantly reduced (p less than 0.01) to 2.4 +/- 2.0 micrograms/12 hr, suggesting that endogenous nitrosation of proline was inhibited. Thus, endogenous nitrosation potential estimated from the difference between NPRO and the sum of nitrosamino acids excreted in the 2 urine samples was significantly higher in subjects positive for the OV antibody. Small amounts of pre-formed nitrosamines were found in fermented fish and pork food items, which are consumed frequently in the high-risk area for CCA. These results suggest that the interaction between chemical carcinogens, especially nitrosamines, and OV infestation may play a role in the development of cholangiocarcinoma in Thailand.

PubMed Disclaimer

Similar articles

• Endogenous nitrosamines and liver fluke as risk factors for cholangiocarcinoma in Thailand.
  Srivatanakul P, Ohshima H, Khlat M, Parkin M, Sukarayodhin S, Brouet I, Bartsch H. Srivatanakul P, et al. IARC Sci Publ. 1991;(105):88-95. IARC Sci Publ. 1991. PMID: 1649794
• Urinary excretion of nitrosamino acids and nitrate by inhabitants of high- and low-risk areas for nasopharyngeal carcinoma in southern China.
  Zeng Y, Ohshima H, Bouvier G, Roy P, Zhong J, Li B, Brouet I, de Thé G, Bartsch H. Zeng Y, et al. Cancer Epidemiol Biomarkers Prev. 1993 May-Jun;2(3):195-200. Cancer Epidemiol Biomarkers Prev. 1993. PMID: 8318871
• High urinary excretion of nitrate and N-nitrosoproline in opisthorchiasis subjects.
  Srianujata S, Tonbuth S, Bunyaratvej S, Valyasevi A, Promvanit N, Chaivatsagul W. Srianujata S, et al. IARC Sci Publ. 1987;(84):544-6. IARC Sci Publ. 1987. PMID: 3679440
• Multistage carcinogenesis of liver-fluke-associated cholangiocarcinoma in Thailand.
  Pairojkul C, Shirai T, Hirohashi S, Thamavit W, Bhudhisawat W, Uttaravicien T, Itoh M, Ito N. Pairojkul C, et al. Princess Takamatsu Symp. 1991;22:77-86. Princess Takamatsu Symp. 1991. PMID: 1668894 Review.
• Diabetes mellitus: Possible risk and promoting factors of cholangiocarcinoma: Association of diabetes mellitus and cholangiocarcinoma.
  Saengboonmee C, Seubwai W, Wongkham C, Wongkham S. Saengboonmee C, et al. Cancer Epidemiol. 2015 Jun;39(3):274-8. doi: 10.1016/j.canep.2015.04.002. Epub 2015 Apr 22. Cancer Epidemiol. 2015. PMID: 25910864 Review.

Cited by

• Liver fluke induces cholangiocarcinoma.
  Sripa B, Kaewkes S, Sithithaworn P, Mairiang E, Laha T, Smout M, Pairojkul C, Bhudhisawasdi V, Tesana S, Thinkamrop B, Bethony JM, Loukas A, Brindley PJ. Sripa B, et al. PLoS Med. 2007 Jul;4(7):e201. doi: 10.1371/journal.pmed.0040201. PLoS Med. 2007. PMID: 17622191 Free PMC article. Review.
• Sustainable Prevention of Cholangiocarcinoma Through Community Participation in a High-incidence Area in Thailand.
  Songserm N, Woradet S, Sripa B, Ali A. Songserm N, et al. Asian Pac J Cancer Prev. 2020 Mar 1;21(3):777-782. doi: 10.31557/APJCP.2020.21.3.777. Asian Pac J Cancer Prev. 2020. PMID: 32212807 Free PMC article.
• Opisthorchiasis and cholangiocarcinoma in Southeast Asia: an unresolved problem.
  Hughes T, O'Connor T, Techasen A, Namwat N, Loilome W, Andrews RH, Khuntikeo N, Yongvanit P, Sithithaworn P, Taylor-Robinson SD. Hughes T, et al. Int J Gen Med. 2017 Aug 10;10:227-237. doi: 10.2147/IJGM.S133292. eCollection 2017. Int J Gen Med. 2017. PMID: 28848361 Free PMC article. Review.
• Prognostic value of DNA alterations on chromosome 17p13.2 for intrahepatic cholangiocarcinoma.
  Chuensumran U, Wongkham S, Pairojkul C, Chauin S, Petmitr S. Chuensumran U, et al. World J Gastroenterol. 2007 Jun 7;13(21):2986-91. doi: 10.3748/wjg.v13.i21.2986. World J Gastroenterol. 2007. PMID: 17589952 Free PMC article.
• Opisthorchis viverrini: the carcinogenic human liver fluke.
  Kaewpitoon N, Kaewpitoon SJ, Pengsaa P, Sripa B. Kaewpitoon N, et al. World J Gastroenterol. 2008 Feb 7;14(5):666-74. doi: 10.3748/wjg.14.666. World J Gastroenterol. 2008. PMID: 18205254 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley

• Medical

  • MedlinePlus Health Information