Evidence for a functional second thymus in mice - PubMed (original) (raw)

. 2006 Apr 14;312(5771):284-7.

doi: 10.1126/science.1123497. Epub 2006 Mar 2.

Affiliations

• PMID: 16513945
• DOI: 10.1126/science.1123497

Evidence for a functional second thymus in mice

Grzegorz Terszowski et al. Science. 2006.

Abstract

The thymus organ supports the development of T cells and is located in the thorax. Here, we report the existence of a second thymus in the mouse neck, which develops after birth and grows to the size of a small lymph node. The cervical thymus had a typical medulla-cortex structure, was found to support T cell development, and could correct T cell deficiency in athymic nude mice upon transplantation. The identification of a regular second thymus in the mouse may provide evolutionary links to thymus organogenesis in other vertebrates and suggests a need to reconsider the effect of thoracic thymectomy on de novo T cell production.

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Comment in

• Immunology. Thoracic thymus, exclusive no longer.
  von Boehmer H. von Boehmer H. Science. 2006 Apr 14;312(5771):206-7. doi: 10.1126/science.1126403. Science. 2006. PMID: 16614204 No abstract available.
• Investigating a second thymus in mice.
  Miller JF. Miller JF. Science. 2006 Jun 16;312(5780):1597-8; author reply 1597-8. doi: 10.1126/science.312.5780.1597c. Science. 2006. PMID: 16778037 No abstract available.

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