Characterization of the Sendai virus V protein with an anti-peptide antiserum - PubMed (original) (raw)
Characterization of the Sendai virus V protein with an anti-peptide antiserum
J Curran et al. Virology. 1991 Sep.
Abstract
The Sendai virus V protein, which is a fusion of the P and V ORFs of the P gene, was characterized with antisera to a portion of the V ORF and compared to the P protein. The only property found in common with P is that V is also highly phosphorylated, and this is so even when these proteins are expressed independently of the other viral proteins. Otherwise, V was not found in virions, was not strongly associated with viral nucleocapsids like P, and anti-V had no effect on viral RNA synthesis in vitro under conditions where anti-P was highly inhibitory. The available evidence suggests that V may play a role in RNA synthesis, but it is not an essential one like that of the P protein.
References
- Barrett T., Shrimpton S.B., Russell S.E.H. Nucleotide sequence of the entire protein coding region of canine distemper virus polymerase-associated (P) protein mRNA. Virus Res. 1985;3:367–372. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources