Association of BRD2 polymorphisms with photoparoxysmal response - PubMed (original) (raw)
Comparative Study
. 2006 May 29;400(1-2):135-9.
doi: 10.1016/j.neulet.2006.02.026. Epub 2006 Mar 3.
Affiliations
- PMID: 16516380
- DOI: 10.1016/j.neulet.2006.02.026
Comparative Study
Association of BRD2 polymorphisms with photoparoxysmal response
Susanne Lorenz et al. Neurosci Lett. 2006.
Abstract
A trait locus for electroencephalographic photoparoxysmal response (PPR) has been mapped to the chromosomal region 6p21 near a susceptibility locus for juvenile myoclonic epilepsy (JME). Linkage disequilibrium mapping revealed strong associations between JME and polymorphisms of the gene encoding the bromodomain-containing protein 2 (BRD2). The present association study tested whether genetic variation of BRD2 confers also susceptibility to PPR. All study participants were of German descent, comprising 187 subjects exhibiting PPR (types I-IV) and 666 healthy controls. Genotypes of each study participant were assessed for seven single nucleotide polymorphisms and one dinucleotide repeat polymorphism, covering the genomic BRD2 sequence. Allelic and haplotypic associations were found between PPR and six BRD2 polymorphisms (P: 0.0075-0.035). Considering the strong neurobiological association of JME and PPR, the present results support evidence that PPR and JME share epileptogenic pathways, for which BRD2 might be an underlying susceptibility gene.
Similar articles
- Genetic susceptibility in Juvenile Myoclonic Epilepsy: Systematic review of genetic association studies.
Santos BPD, Marinho CRM, Marques TEBS, Angelo LKG, Malta MVDS, Duzzioni M, Castro OW, Leite JP, Barbosa FT, Gitaí DLG. Santos BPD, et al. PLoS One. 2017 Jun 21;12(6):e0179629. doi: 10.1371/journal.pone.0179629. eCollection 2017. PLoS One. 2017. PMID: 28636645 Free PMC article. Review. - BRD2 and TAP-1 genes and juvenile myoclonic epilepsy.
Layouni S, Buresi C, Thomas P, Malafosse A, Dogui M. Layouni S, et al. Neurol Sci. 2010 Feb;31(1):53-6. doi: 10.1007/s10072-009-0190-z. Epub 2009 Dec 2. Neurol Sci. 2010. PMID: 19953286 - BRD2 (RING3) is a probable major susceptibility gene for common juvenile myoclonic epilepsy.
Pal DK, Evgrafov OV, Tabares P, Zhang F, Durner M, Greenberg DA. Pal DK, et al. Am J Hum Genet. 2003 Aug;73(2):261-70. doi: 10.1086/377006. Epub 2003 Jun 25. Am J Hum Genet. 2003. PMID: 12830434 Free PMC article. - A multicenter study of BRD2 as a risk factor for juvenile myoclonic epilepsy.
Cavalleri GL, Walley NM, Soranzo N, Mulley J, Doherty CP, Kapoor A, Depondt C, Lynch JM, Scheffer IE, Heils A, Gehrmann A, Kinirons P, Gandhi S, Satishchandra P, Wood NW, Anand A, Sander T, Berkovic SF, Delanty N, Goldstein DB, Sisodiya SM. Cavalleri GL, et al. Epilepsia. 2007 Apr;48(4):706-12. doi: 10.1111/j.1528-1167.2007.00977.x. Epilepsia. 2007. PMID: 17437413 - Genetics of photosensitivity (photoparoxysmal response): a review.
Stephani U, Tauer U, Koeleman B, Pinto D, Neubauer BA, Lindhout D. Stephani U, et al. Epilepsia. 2004;45 Suppl 1:19-23. doi: 10.1111/j.0013-9580.2004.451008.x. Epilepsia. 2004. PMID: 14706040 Review.
Cited by
- Syntaxin 1B Mediates Berberine's Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model.
Zheng YM, Chen B, Jiang JD, Zhang JP. Zheng YM, et al. Front Mol Neurosci. 2018 Nov 26;11:378. doi: 10.3389/fnmol.2018.00378. eCollection 2018. Front Mol Neurosci. 2018. PMID: 30534049 Free PMC article. - DNA methylation of the BRD2 promoter is associated with juvenile myoclonic epilepsy in Caucasians.
Pathak S, Miller J, Morris EC, Stewart WCL, Greenberg DA. Pathak S, et al. Epilepsia. 2018 May;59(5):1011-1019. doi: 10.1111/epi.14058. Epub 2018 Apr 2. Epilepsia. 2018. PMID: 29608786 Free PMC article. - Genetic susceptibility in Juvenile Myoclonic Epilepsy: Systematic review of genetic association studies.
Santos BPD, Marinho CRM, Marques TEBS, Angelo LKG, Malta MVDS, Duzzioni M, Castro OW, Leite JP, Barbosa FT, Gitaí DLG. Santos BPD, et al. PLoS One. 2017 Jun 21;12(6):e0179629. doi: 10.1371/journal.pone.0179629. eCollection 2017. PLoS One. 2017. PMID: 28636645 Free PMC article. Review. - Quantitative magnetic resonance imaging traits as endophenotypes for genetic mapping in epilepsy.
Alhusaini S, Whelan CD, Sisodiya SM, Thompson PM. Alhusaini S, et al. Neuroimage Clin. 2016 Sep 8;12:526-534. doi: 10.1016/j.nicl.2016.09.005. eCollection 2016. Neuroimage Clin. 2016. PMID: 27672556 Free PMC article. Review. - Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function.
Bagley JA, Yan Z, Zhang W, Wildonger J, Jan LY, Jan YN. Bagley JA, et al. Genes Dev. 2014 Sep 1;28(17):1940-56. doi: 10.1101/gad.239962.114. Genes Dev. 2014. PMID: 25184680 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous