The biology of incretin hormones - PubMed (original) (raw)

Review

The biology of incretin hormones

Daniel J Drucker. Cell Metab. 2006 Mar.

Free article

Abstract

Gut peptides, exemplified by glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted in a nutrient-dependent manner and stimulate glucose-dependent insulin secretion. Both GIP and GLP-1 also promote beta cell proliferation and inhibit apoptosis, leading to expansion of beta cell mass. GLP-1, but not GIP, controls glycemia via additional actions on glucose sensors, inhibition of gastric emptying, food intake and glucagon secretion. Furthermore, GLP-1, unlike GIP, potently stimulates insulin secretion and reduces blood glucose in human subjects with type 2 diabetes. This article summarizes current concepts of incretin action and highlights the potential therapeutic utility of GLP-1 receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors for the treatment of type 2 diabetes.

PubMed Disclaimer

Similar articles

• The incretin hormones GIP and GLP-1 in diabetic rats: effects on insulin secretion and small bowel motility.
  Edholm T, Cejvan K, Abdel-Halim SM, Efendic S, Schmidt PT, Hellström PM. Edholm T, et al. Neurogastroenterol Motil. 2009 Mar;21(3):313-21. doi: 10.1111/j.1365-2982.2008.01229.x. Epub 2008 Dec 18. Neurogastroenterol Motil. 2009. PMID: 19126188
• What do we know about the secretion and degradation of incretin hormones?
  Deacon CF. Deacon CF. Regul Pept. 2005 Jun 15;128(2):117-24. doi: 10.1016/j.regpep.2004.06.007. Regul Pept. 2005. PMID: 15780431 Review.
• [Analogs of glucagon-like peptide-1 (GLP-1): an old concept as a new treatment of patients with diabetes mellitus type 2].
  Diamant M, Bunck MC, Heine RJ. Diamant M, et al. Ned Tijdschr Geneeskd. 2004 Sep 25;148(39):1912-7. Ned Tijdschr Geneeskd. 2004. PMID: 15495988 Review. Dutch.
• Role of the incretin pathway in the pathogenesis of type 2 diabetes mellitus.
  Freeman JS. Freeman JS. Cleve Clin J Med. 2009 Dec;76 Suppl 5:S12-9. doi: 10.3949/ccjm.76.s5.03. Cleve Clin J Med. 2009. PMID: 19952298 Review.
• A comparison of the cellular and biological properties of DPP-IV-resistant N-glucitol analogues of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide.
  Green BD, Gault VA, O'Harte FP, Flatt PR. Green BD, et al. Diabetes Obes Metab. 2005 Sep;7(5):595-604. doi: 10.1111/j.1463-1326.2004.00455.x. Diabetes Obes Metab. 2005. PMID: 16050953

Cited by

• Glucagon-like peptide-1 receptor: mechanisms and advances in therapy.
  Zheng Z, Zong Y, Ma Y, Tian Y, Pang Y, Zhang C, Gao J. Zheng Z, et al. Signal Transduct Target Ther. 2024 Sep 18;9(1):234. doi: 10.1038/s41392-024-01931-z. Signal Transduct Target Ther. 2024. PMID: 39289339 Free PMC article. Review.
• Mechanisms of ferroptosis and glucagon-like peptide-1 receptor agonist in post-percutaneous coronary intervention restenosis.
  Wang M, Wang L, Sun H, Yuan H, Li Y. Wang M, et al. Mol Cell Biochem. 2024 Sep 16. doi: 10.1007/s11010-024-05118-6. Online ahead of print. Mol Cell Biochem. 2024. PMID: 39283562 Review.
• Glucose-Dependent Insulinotropic Polypeptide Inhibits AGE-Induced NADPH Oxidase-Derived Oxidative Stress Generation and Foam Cell Formation in Macrophages Partly via AMPK Activation.
  Terasaki M, Yashima H, Mori Y, Saito T, Inoue N, Matsui T, Osaka N, Fujikawa T, Ohara M, Yamagishi SI. Terasaki M, et al. Int J Mol Sci. 2024 Sep 8;25(17):9724. doi: 10.3390/ijms25179724. Int J Mol Sci. 2024. PMID: 39273671 Free PMC article.
• GLP-1 receptor agonist exenatide uncouples food intake from hedonic and anticipatory regulation in non-human primates: insights from an operant meal schedule paradigm.
  Knakker B, Inkeller J, Kovács P, Lendvai B, Hernádi I. Knakker B, et al. Neuropsychopharmacology. 2024 Sep 4. doi: 10.1038/s41386-024-01981-5. Online ahead of print. Neuropsychopharmacology. 2024. PMID: 39232188
• Circulating pancreatic enzyme levels are a causal biomarker of type 1 diabetes.
  Elgamal RM, Melton RL, Chiou J, McGrail CW, Gaulton KJ. Elgamal RM, et al. medRxiv [Preprint]. 2024 Aug 9:2024.08.08.24311619. doi: 10.1101/2024.08.08.24311619. medRxiv. 2024. PMID: 39148858 Free PMC article. Preprint.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations

• Miscellaneous

  • NCI CPTAC Assay Portal