T cell responses in dengue hemorrhagic fever: are cross-reactive T cells suboptimal? - PubMed (original) (raw)

. 2006 Mar 15;176(6):3821-9.

doi: 10.4049/jimmunol.176.6.3821.

Thaneeya Duangchinda, Wanwisa Dejnirattisai, Sirijit Vasanawathana, Panisadee Avirutnan, Aroonroong Jairungsri, Nuanpan Khemnu, Nattaya Tangthawornchaikul, Pojchong Chotiyarnwong, Kanokwan Sae-Jang, Michael Koch, Yvonne Jones, Andrew McMichael, Xiaoning Xu, Prida Malasit, Gavin Screaton

Affiliations

Free article

T cell responses in dengue hemorrhagic fever: are cross-reactive T cells suboptimal?

Juthathip Mongkolsapaya et al. J Immunol. 2006.

Free article

Abstract

Dengue virus infection poses a growing public health and economic burden in a number of tropical and subtropical countries. Dengue circulates as a number of quasispecies, which can be divided by serology into four groups or serotypes. An interesting feature of Dengue, recognized over five decades ago, is that most severe cases that show hemorrhagic fever are not suffering from a primary infection. Instead, they are reinfected with a virus of different serotype. This observation poses considerable problems in vaccine design, and it is therefore imperative to gain a full understanding of the mechanisms underlying this immunological enhancement of disease. In this study, we examined a T cell epitope restricted by HLA-A*24, a major MHC class I allele, in Southeast Asia in a cohort of children admitted to a hospital with acute Dengue infection. The cytokine profiles and the degranulation capacity of T cells generated to this epitope are defined and compared across different viral serotypes. Cross-reactive Dengue-specific T cells seem to show suboptimal degranulation but high cytokine production, which may contribute to the development of the vascular leak characteristic of Dengue hemorrhagic fever.

PubMed Disclaimer

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources