Coordinated control of renal Ca2+ handling - PubMed (original) (raw)
Review
Coordinated control of renal Ca2+ handling
T T Lambers et al. Kidney Int. 2006 Feb.
Free article
Abstract
Ca2+ homeostasis is an important factor, which is underlined by the numerous clinical symptoms that involve Ca2+ deficiencies. The overall Ca2+ balance is maintained by the concerted action of Ca2+ absorption in the intestine, reabsorption in the kidney, and exchange from bone, which are all under the control of the calciotropic hormones that are released upon a demand for Ca2+. In the kidney, these calciotropic hormones affect active Ca2+ reabsorption, which consists of TRPV5 as the apical entry gate for Ca2+ influx, calbindin-D28K as an intracellular ferry for Ca2+ and, NCX1 and PMCA1b for extrusion of Ca2+ across the basolateral membrane. This review highlights the action of hormones on renal Ca2+ handling and focuses on the coordinated control of the renal Ca2+ transport proteins. Parathyroid hormone stimulates renal Ca2+ handling by regulating active Ca2+ reabsorption on both the genomic and non-genomic level. Estrogens harbor calciotropic hormone characteristics positively regulating the expression of TRPV5, independently of vitamin D. Besides having a strong regulatory effect on the expression of the intestinal Ca2+ transport proteins, vitamin D contributes to the overall Ca2+ balance by enhancing the expression of the Ca2+ transport machinery in the kidney. Dietary Ca2+ is involved in regulating its own handling by controlling the expression of the renal Ca2+ transport proteins. Thus, the magnitude of Ca2+ entry via TRPV5 controls the expression of the other Ca2+ transport proteins underlining the gatekeeper function of this Ca2+ channel in the renal Ca2+ handling.
Similar articles
- Modulation of renal Ca2+ transport protein genes by dietary Ca2+ and 1,25-dihydroxyvitamin D3 in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice.
Hoenderop JG, Dardenne O, Van Abel M, Van Der Kemp AW, Van Os CH, St -Arnaud R, Bindels RJ. Hoenderop JG, et al. FASEB J. 2002 Sep;16(11):1398-406. doi: 10.1096/fj.02-0225com. FASEB J. 2002. PMID: 12205031 - Critical role of the epithelial Ca2+ channel TRPV5 in active Ca2+ reabsorption as revealed by TRPV5/calbindin-D28K knockout mice.
Gkika D, Hsu YJ, van der Kemp AW, Christakos S, Bindels RJ, Hoenderop JG. Gkika D, et al. J Am Soc Nephrol. 2006 Nov;17(11):3020-7. doi: 10.1681/ASN.2006060676. Epub 2006 Sep 27. J Am Soc Nephrol. 2006. PMID: 17005931 - Active Ca(2+) reabsorption in the connecting tubule.
Boros S, Bindels RJ, Hoenderop JG. Boros S, et al. Pflugers Arch. 2009 May;458(1):99-109. doi: 10.1007/s00424-008-0602-6. Epub 2008 Nov 7. Pflugers Arch. 2009. PMID: 18989697 Review. - Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice *.
Oz OK, Hajibeigi A, Howard K, Cummins CL, van Abel M, Bindels RJ, Word RA, Kuro-o M, Pak CY, Zerwekh JE. Oz OK, et al. J Bone Miner Res. 2007 Dec;22(12):1893-902. doi: 10.1359/jbmr.070808. J Bone Miner Res. 2007. PMID: 17708714 - Renal and intestinal calcium transport: roles of vitamin D and vitamin D-dependent calcium binding proteins.
Johnson JA, Kumar R. Johnson JA, et al. Semin Nephrol. 1994 Mar;14(2):119-28. Semin Nephrol. 1994. PMID: 8177979 Review.
Cited by
- Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport.
Lambers TT, Mahieu F, Oancea E, Hoofd L, de Lange F, Mensenkamp AR, Voets T, Nilius B, Clapham DE, Hoenderop JG, Bindels RJ. Lambers TT, et al. EMBO J. 2006 Jul 12;25(13):2978-88. doi: 10.1038/sj.emboj.7601186. Epub 2006 Jun 8. EMBO J. 2006. PMID: 16763551 Free PMC article. - Effect of Occupational Cadmium Exposure on Parathyroid Gland.
Ibrahim KS, Beshir S, Shahy EM, Shaheen W. Ibrahim KS, et al. Open Access Maced J Med Sci. 2016 Jun 15;4(2):302-6. doi: 10.3889/oamjms.2016.042. Epub 2016 Mar 21. Open Access Maced J Med Sci. 2016. PMID: 27335606 Free PMC article. - FGF23 promotes renal calcium reabsorption through the TRPV5 channel.
Andrukhova O, Smorodchenko A, Egerbacher M, Streicher C, Zeitz U, Goetz R, Shalhoub V, Mohammadi M, Pohl EE, Lanske B, Erben RG. Andrukhova O, et al. EMBO J. 2014 Feb 3;33(3):229-46. doi: 10.1002/embj.201284188. Epub 2014 Jan 16. EMBO J. 2014. PMID: 24434184 Free PMC article. - Reduced secretion of parathyroid hormone and hypocalcemia in systemic heterozygous ATP2B1-null hypertensive mice.
Ehara Y, Hirawa N, Sumida K, Fujiwara A, Kagimoto M, Ooki-Okuyama Y, Fujita M, Katsumata M, Kobayashi Y, Saka S, Katou I, Yatsu K, Umemura S, Tamura K. Ehara Y, et al. Hypertens Res. 2018 Sep;41(9):699-707. doi: 10.1038/s41440-018-0067-8. Epub 2018 Jun 27. Hypertens Res. 2018. PMID: 29950683 Free PMC article. - Disorders involving calcium, phosphorus, and magnesium.
Moe SM. Moe SM. Prim Care. 2008 Jun;35(2):215-37, v-vi. doi: 10.1016/j.pop.2008.01.007. Prim Care. 2008. PMID: 18486714 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous