Specific immunity and nonspecific resistance to infection: listeria, protozoa, and viruses in mice and hamsters, - PubMed (original) (raw)
Specific immunity and nonspecific resistance to infection: listeria, protozoa, and viruses in mice and hamsters,
J K Frenkel et al. J Infect Dis. 1975 Mar.
Abstract
Specific immunity developed by mice against protozoan (Toxoplasma gondii and Besnoitia jellisoni) and bacterial (Listeria monocytogenes) infections was compared with nonspecific protection conferred by prior infections. The results indicated that homologous immunity protected mice from more than 10-5 LD50 of T. gondii or B. jellisoni, but from only 10-2 LD50 of L. monocytogenes. Heterospecific protection among these organisms was for 10-0.4 minus 10-1.2 LD50. In studies in hamsters specific immunity to protozoan (T. gondii and B. jellisoni) and viral (equine Herpesvirus type 1 and Oriboca virus) infections was compared with nonspecific protection conferred by prior infections with several heterospecific agents: T. gondii; B. jellison; equine Herpesvirus type 1; Oriboca, Ossa, vesicular stomatitis, yellow fever, and Newcastle disease viruses; L. monocytogenes; and the bacillus Calmette-Guerin strain of Mycobacterium tuberculosis. The results indicated that homologous immunity in hamsters was effective against 10-6 minus 10-7 LD50 of T. gondii, B. jellisoni, equine Herpesvirus type 1, or Oriboca virus. Prior infection with Newcastle disease virus protected (probably by interferon induction) against 10-3 LD50 of equine Herpesvirus type 1. Heterospecific protection among other agents was for less than 10 LD50. This insignificant heterospecific protection in infections in which cellular immunity plays a role suggests that both the induction phase and the expression phase are specific.
Similar articles
- A comparison of cross protection between BCG, Hammondia hammondi, Besnoitia jellisoni and Toxoplasma gondii in hamsters.
Dubey JP. Dubey JP. J Protozool. 1978 Aug;25(3 Pt 2):382-4. doi: 10.1111/j.1550-7408.1978.tb03910.x. J Protozool. 1978. PMID: 364045 - Mediation of immunity to intracellular infection (Toxoplasma and Besnoitia) within somatic cells.
Chinchilla M, Frenkel JK. Chinchilla M, et al. Infect Immun. 1978 Mar;19(3):999-1012. doi: 10.1128/iai.19.3.999-1012.1978. Infect Immun. 1978. PMID: 640741 Free PMC article. - Cell-mediated immunity against Besnoitia and toxoplasma in specifically and cross-immunized hamsters and in cultures.
Hoff RL, Frenkel JK. Hoff RL, et al. J Exp Med. 1974 Mar 1;139(3):560-80. doi: 10.1084/jem.139.3.560. J Exp Med. 1974. PMID: 4812629 Free PMC article. - p47 GTPases: regulators of immunity to intracellular pathogens.
Taylor GA, Feng CG, Sher A. Taylor GA, et al. Nat Rev Immunol. 2004 Feb;4(2):100-9. doi: 10.1038/nri1270. Nat Rev Immunol. 2004. PMID: 15040583 Review. - Protozoa: Pathogenesis and Defenses.
Seed JR. Seed JR. In: Baron S, editor. Medical Microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Chapter 78. In: Baron S, editor. Medical Microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Chapter 78. PMID: 21413293 Free Books & Documents. Review.
Cited by
- The Unspecific Side of Acquired Immunity Against Infectious Disease: Causes and Consequences.
Muraille E. Muraille E. Front Microbiol. 2016 Jan 11;6:1525. doi: 10.3389/fmicb.2015.01525. eCollection 2015. Front Microbiol. 2016. PMID: 26793171 Free PMC article. Review. - Gut colonization of mice with actA-negative mutant of Listeria monocytogenes can stimulate a humoral mucosal immune response.
Manohar M, Baumann DO, Bos NA, Cebra JJ. Manohar M, et al. Infect Immun. 2001 Jun;69(6):3542-9. doi: 10.1128/IAI.69.6.3542-3549.2001. Infect Immun. 2001. PMID: 11349011 Free PMC article. - Resistance to Cryptococcus neoformans is associated with an inflammatory response to Toxoplasma gondii in the central nervous system of mice.
Aguirre KM, Sayles PC, Gibson GW, Johnson LL. Aguirre KM, et al. Infect Immun. 1996 Jan;64(1):77-82. doi: 10.1128/iai.64.1.77-82.1996. Infect Immun. 1996. PMID: 8557377 Free PMC article. - Toxoplasmosis in immunoglobulin M-suppressed mice.
Frenkel JK, Taylor DW. Frenkel JK, et al. Infect Immun. 1982 Oct;38(1):360-7. doi: 10.1128/iai.38.1.360-367.1982. Infect Immun. 1982. PMID: 6982863 Free PMC article. - Lymphocyte subpopulations and function in chronic murine toxoplasmosis.
Macario AJ, Stahl W, Miller R. Macario AJ, et al. Clin Exp Immunol. 1980 Sep;41(3):415-22. Clin Exp Immunol. 1980. PMID: 6969157 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources