A long-distance relationship between RNAi and Polycomb - PubMed (original) (raw)
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. 2006 Mar 10;124(5):886-8.
doi: 10.1016/j.cell.2006.02.026.
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- PMID: 16530034
- DOI: 10.1016/j.cell.2006.02.026
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A long-distance relationship between RNAi and Polycomb
Elissa P Lei et al. Cell. 2006.
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Abstract
RNA interference (RNAi) pathways can result in sequence-specific transcriptional gene silencing on the level of chromatin. In this issue of Cell, Grimaud et al. (2006) reveal that the RNAi machinery is required for long-distance physical interactions between chromosomes mediated by the Polycomb repressive complex. These results suggest that the RNAi machinery may regulate higher-order nuclear organization.
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- RNAi components are required for nuclear clustering of Polycomb group response elements.
Grimaud C, Bantignies F, Pal-Bhadra M, Ghana P, Bhadra U, Cavalli G. Grimaud C, et al. Cell. 2006 Mar 10;124(5):957-71. doi: 10.1016/j.cell.2006.01.036. Cell. 2006. PMID: 16530043
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