Small GTPase Rnd1 is involved in neuronal activity-dependent dendritic development in hippocampal neurons - PubMed (original) (raw)
. 2006 Jun 12;400(3):218-23.
doi: 10.1016/j.neulet.2006.02.064. Epub 2006 Mar 10.
Affiliations
- PMID: 16530331
- DOI: 10.1016/j.neulet.2006.02.064
Small GTPase Rnd1 is involved in neuronal activity-dependent dendritic development in hippocampal neurons
Yukio Ishikawa et al. Neurosci Lett. 2006.
Abstract
Rho family small GTPases are key regulators for neuronal morphogenesis including dendritogenesis. We recently have shown that Rnd1, a member of the Rho family, is highly expressed in brain during the synaptogenic stage and is involved in dendritic spine formation. However, the mechanism by which Rnd1 regulates dendritic development including spine morphogenesis remains unknown. Here we report that Rnd1, a member of the Rho family, plays a critical role in neuronal activity-dependent dendritic development in hippocampal neurons. Overexpression of Rnd1 promoted dendritic growth and branching in cultured hippocampal neurons. On the other hand, suppression of endogenous Rnd1 expression by RNA interference significantly inhibited neuronal activity-dependent dendritic development and this inhibitory effect was canceled by inhibition of RhoA effector ROCK. In addition, knockdown of Rnd1 also abolished dendritic development promoted by treatment with brain-derived neurotrophic factor in hippocampal neurons. Our findings demonstrate that Rnd1 is involved in signaling pathways of neuronal activity-dependent dendritic development.
Similar articles
- A role of Rnd1 GTPase in dendritic spine formation in hippocampal neurons.
Ishikawa Y, Katoh H, Negishi M. Ishikawa Y, et al. J Neurosci. 2003 Dec 3;23(35):11065-72. doi: 10.1523/JNEUROSCI.23-35-11065.2003. J Neurosci. 2003. PMID: 14657163 Free PMC article. - Dock4 regulates dendritic development in hippocampal neurons.
Ueda S, Fujimoto S, Hiramoto K, Negishi M, Katoh H. Ueda S, et al. J Neurosci Res. 2008 Nov 1;86(14):3052-61. doi: 10.1002/jnr.21763. J Neurosci Res. 2008. PMID: 18615735 - Differential effects of Rho GTPases on axonal and dendritic development in hippocampal neurones.
Ahnert-Hilger G, Höltje M, Grosse G, Pickert G, Mucke C, Nixdorf-Bergweiler B, Boquet P, Hofmann F, Just I. Ahnert-Hilger G, et al. J Neurochem. 2004 Jul;90(1):9-18. doi: 10.1111/j.1471-4159.2004.02475.x. J Neurochem. 2004. PMID: 15198662 - Rho GTPases, dendritic structure, and mental retardation.
Newey SE, Velamoor V, Govek EE, Van Aelst L. Newey SE, et al. J Neurobiol. 2005 Jul;64(1):58-74. doi: 10.1002/neu.20153. J Neurobiol. 2005. PMID: 15884002 Review. - Intracellular signaling pathways that regulate dendritic spine morphogenesis.
Nakayama AY, Luo L. Nakayama AY, et al. Hippocampus. 2000;10(5):582-6. doi: 10.1002/1098-1063(2000)10:5<582::AID-HIPO8>3.0.CO;2-K. Hippocampus. 2000. PMID: 11075828 Review.
Cited by
- RND1 inhibits epithelial-mesenchymal transition and temozolomide resistance of glioblastoma via AKT/GSK3-β pathway.
Sun Q, Xu J, Yuan F, Liu Y, Chen Q, Guo L, Dong H, Liu B. Sun Q, et al. Cancer Biol Ther. 2024 Dec 31;25(1):2321770. doi: 10.1080/15384047.2024.2321770. Epub 2024 Mar 5. Cancer Biol Ther. 2024. PMID: 38444223 Free PMC article. - What Is the Role of the Rho-ROCK Pathway in Neurologic Disorders?
Benarroch E. Benarroch E. Neurology. 2023 Sep 19;101(12):536-543. doi: 10.1212/WNL.0000000000207779. Neurology. 2023. PMID: 37722862 Free PMC article. No abstract available. - TRP Channels Regulation of Rho GTPases in Brain Context and Diseases.
Lavanderos B, Silva I, Cruz P, Orellana-Serradell O, Saldías MP, Cerda O. Lavanderos B, et al. Front Cell Dev Biol. 2020 Nov 10;8:582975. doi: 10.3389/fcell.2020.582975. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 33240883 Free PMC article. Review. - p39-associated Cdk5 activity regulates dendritic morphogenesis.
Ouyang L, Chen Y, Wang Y, Chen Y, Fu AKY, Fu WY, Ip NY. Ouyang L, et al. Sci Rep. 2020 Oct 30;10(1):18746. doi: 10.1038/s41598-020-75264-6. Sci Rep. 2020. PMID: 33127972 Free PMC article. - Pathophysiological functions of Rnd proteins.
Basbous S, Azzarelli R, Pacary E, Moreau V. Basbous S, et al. Small GTPases. 2021 Sep-Nov;12(5-6):336-357. doi: 10.1080/21541248.2020.1829914. Epub 2020 Oct 15. Small GTPases. 2021. PMID: 33054516 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases