Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF - PubMed (original) (raw)

. 1991 Sep 6;253(5024):1129-32.

doi: 10.1126/science.1653454.

Affiliations

• PMID: 1653454
• DOI: 10.1126/science.1653454

Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF

G A Ferns et al. Science. 1991.

Abstract

Approximately 30 to 40 percent of atherosclerotic coronary arteries treated by angioplasty or by bypass surgery occlude as a result of restenosis. This restenosis is due principally to the accumulation of neointimal smooth muscle cells, which is also a prominent feature of the advanced lesions of atherosclerosis. The factors responsible for the accumulation of intimal smooth muscle cells have not been identified. Platelet-derived growth factor (PDGF) is a potent smooth muscle chemoattractant and mitogen. It is present in platelets and can be formed by endothelium, smooth muscle, and monocyte-derived macrophages. The development of an intimal lesion in the carotid artery of athymic nude rats induced by intraarterial balloon catheter deendothelialization was inhibited by a polyclonal antibody to PDGF. These data demonstrate that endogenous PDGF is involved in the accumulation of neointimal smooth muscle cells associated with balloon injury and may be involved in restenosis after angioplasty, and perhaps in atherogenesis as well.

PubMed Disclaimer

Similar articles

• Balloon catheter de-endothelialization of the nude rat carotid. Response to injury in the absence of functional T lymphocytes.
  Ferns GA, Reidy MA, Ross R. Ferns GA, et al. Am J Pathol. 1991 Apr;138(4):1045-57. Am J Pathol. 1991. PMID: 1849358 Free PMC article.
• Substantial inhibition of neo-intimal response to balloon injury in the rat carotid artery using a combination of antibodies to platelet-derived growth factor-BB and basic fibroblast growth factor.
  Rutherford C, Martin W, Salame M, Carrier M, Anggård E, Ferns G. Rutherford C, et al. Atherosclerosis. 1997 Apr;130(1-2):45-51. doi: 10.1016/s0021-9150(96)06042-x. Atherosclerosis. 1997. PMID: 9126647
• Osteopontin expression in platelet-derived growth factor-stimulated vascular smooth muscle cells and carotid artery after balloon angioplasty.
  Wang X, Louden C, Ohlstein EH, Stadel JM, Gu JL, Yue TL. Wang X, et al. Arterioscler Thromb Vasc Biol. 1996 Nov;16(11):1365-72. doi: 10.1161/01.atv.16.11.1365. Arterioscler Thromb Vasc Biol. 1996. PMID: 8911275
• A cascade model for restenosis. A special case of atherosclerosis progression.
  Libby P, Schwartz D, Brogi E, Tanaka H, Clinton SK. Libby P, et al. Circulation. 1992 Dec;86(6 Suppl):III47-52. Circulation. 1992. PMID: 1424051 Review.
• The role of hyaluronan and its receptors in restenosis after balloon angioplasty: development of a potential therapy.
  Savani RC, Turley EA. Savani RC, et al. Int J Tissue React. 1995;17(4):141-51. Int J Tissue React. 1995. PMID: 8867644 Review.

Cited by

• Curcumin's Effect on Inflammatory Response following Percutaneous Coronary Intervention in Adult Patients with Stable Coronary Heart Disease.
  Silalahi T, Alwi I, Suyatna F, Sartika KD. Silalahi T, et al. Int J Angiol. 2021 Jun;30(2):132-138. doi: 10.1055/s-0040-1720969. Epub 2021 Jan 29. Int J Angiol. 2021. PMID: 34054271 Free PMC article.
• Pioglitazone Ameliorates Smooth Muscle Cell Proliferation in Cuff-Induced Neointimal Formation by Both Adiponectin-Dependent and -Independent Pathways.
  Kubota T, Kubota N, Sato H, Inoue M, Kumagai H, Iwamura T, Takamoto I, Kobayashi T, Moroi M, Terauchi Y, Tobe K, Ueki K, Kadowaki T. Kubota T, et al. Sci Rep. 2016 Oct 5;6:34707. doi: 10.1038/srep34707. Sci Rep. 2016. PMID: 27703271 Free PMC article.
• Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway.
  Li G, Jin R, Norris RA, Zhang L, Yu S, Wu F, Markwald RR, Nanda A, Conway SJ, Smyth SS, Granger DN. Li G, et al. Atherosclerosis. 2010 Feb;208(2):358-65. doi: 10.1016/j.atherosclerosis.2009.07.046. Epub 2009 Jul 30. Atherosclerosis. 2010. PMID: 19695571 Free PMC article.
• Receptor interacting protein 3 suppresses vascular smooth muscle cell growth by inhibition of the phosphoinositide 3-kinase-Akt axis.
  Li Q, Li G, Lan X, Zheng M, Chen KH, Cao CM, Xiao RP. Li Q, et al. J Biol Chem. 2010 Mar 26;285(13):9535-9544. doi: 10.1074/jbc.M109.071332. Epub 2009 Dec 30. J Biol Chem. 2010. PMID: 20042608 Free PMC article.
• Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse.
  Lilly B, Clark KA, Yoshigi M, Pronovost S, Wu ML, Periasamy M, Chi M, Paul RJ, Yet SF, Beckerle MC. Lilly B, et al. Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):694-701. doi: 10.1161/ATVBAHA.109.200741. Epub 2010 Jan 7. Arterioscler Thromb Vasc Biol. 2010. PMID: 20056913 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon

• Other Literature Sources

  • The Lens - Patent Citations Database