CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma - PubMed (original) (raw)
. 2006 Mar 16;354(11):1117-29.
doi: 10.1056/NEJMoa053614.
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- PMID: 16540612
- DOI: 10.1056/NEJMoa053614
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CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma
Omid Akbari et al. N Engl J Med. 2006.
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Abstract
Background: Bronchial asthma is associated with an inflammatory process that is characterized by the presence in the airways of large numbers of CD4+ T cells producing interleukin-4 and interleukin-13. However, the CD4 antigen is expressed not only by class II major histocompatibility complex (MHC)-restricted CD4+ T cells, but also by a newly identified subgroup of T cells, CD1d-restricted natural killer T cells. These cells express a conserved (invariant) T-cell receptor and have a potent immunoregulatory function. Because mouse models of allergic asthma indicate that natural killer T cells are required for the development of allergen-induced airway hyperreactivity, we hypothesized that natural killer T cells play an important role in human asthma.
Methods: We used CD1d-tetramers, antibodies specific for natural killer T cells, as well as reverse-transcriptase-polymerase-chain-reaction analysis of the invariant T-cell receptor of natural killer T cells to assess the frequency and distribution of natural killer T cells in the lungs and in the circulating blood of 14 patients with asthma.
Results: About 60 percent of the pulmonary CD4+CD3+ cells in patients with moderate-to-severe persistent asthma were not class II MHC-restricted CD4+ T cells but, rather, natural killer T cells. The natural killer T cells expressed an invariant T-cell receptor and produced type 2 helper cytokines. In contrast, the CD4+ T cells found in the lungs of patients with sarcoidosis were conventional CD4+CD3+ T cells, not natural killer T cells.
Conclusions: Together with studies in mice indicating a requirement for natural killer T cells in the development of allergen-induced airway hyperreactivity, our results strongly suggest that CD4+ natural killer T cells play a prominent pathogenic role in human asthma.
Copyright 2006 Massachusetts Medical Society.
Comment in
- Natural killer T cells and asthma.
Kay AB. Kay AB. N Engl J Med. 2006 Mar 16;354(11):1186-8. doi: 10.1056/NEJMe068024. N Engl J Med. 2006. PMID: 16540620 No abstract available. - Invariant natural killer T cells in bronchial asthma.
Thomas SY, Lilly CM, Luster AD. Thomas SY, et al. N Engl J Med. 2006 Jun 15;354(24):2613-6; author reply 2613-6. doi: 10.1056/NEJMc066189. N Engl J Med. 2006. PMID: 16775244 No abstract available. - Invariant natural killer T cells in bronchial asthma.
Pham-Thi N, de Blic J, Leite-de-Moraes MC. Pham-Thi N, et al. N Engl J Med. 2006 Jun 15;354(24):2613-6; author reply 2613-6. N Engl J Med. 2006. PMID: 16775881 No abstract available. - Natural killer T cells in asthma--toward increased understanding.
Ho LP. Ho LP. N Engl J Med. 2007 Apr 5;356(14):1466-8. doi: 10.1056/NEJMe078014. N Engl J Med. 2007. PMID: 17409330 No abstract available. - Invariant natural killer T cells in obstructive pulmonary diseases.
Bratke K, Julius P, Virchow JC. Bratke K, et al. N Engl J Med. 2007 Jul 12;357(2):194; author reply 194-5. N Engl J Med. 2007. PMID: 17632897 No abstract available.
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