GABAA receptors are differentially sensitive to zinc: dependence on subunit composition - PubMed (original) (raw)

GABAA receptors are differentially sensitive to zinc: dependence on subunit composition

T G Smart et al. Br J Pharmacol. 1991 Aug.

Abstract

GABAA receptors with different subunit composition, were expressed in kidney cells and studied by whole cell recording. Expressed GABAA receptors were differentially sensitive to inhibition by zinc; receptors which lacked the gamma subunit were inhibited by zinc. Embryonic neurons also exhibited zinc-sensitive GABA responses, in contrast to adult neurones. This developmentally-sensitive aspect of GABAA receptor pharmacology may be partly dependent on expression of the gamma subunit.

PubMed Disclaimer

Similar articles

• A novel modulatory binding site for zinc on the GABAA receptor complex in cultured rat neurones.
  Smart TG. Smart TG. J Physiol. 1992 Feb;447:587-625. doi: 10.1113/jphysiol.1992.sp019020. J Physiol. 1992. PMID: 1375632 Free PMC article.
• Lanthanum and zinc sensitivity of GABAA-activated currents in adult medial septum/diagonal band neurons from ethanol dependent rats.
  Frye GD, Fincher AS, Grover CA, Jayaprabhu S. Frye GD, et al. Brain Res. 1996 May 13;720(1-2):101-10. doi: 10.1016/0006-8993(96)00154-0. Brain Res. 1996. PMID: 8782902
• Differential effect of zinc on the vertebrate GABAA-receptor complex.
  Smart TG, Constanti A. Smart TG, et al. Br J Pharmacol. 1990 Apr;99(4):643-54. doi: 10.1111/j.1476-5381.1990.tb12984.x. Br J Pharmacol. 1990. PMID: 2163276 Free PMC article.
• Zinc and flunitrazepam modulation of GABA-mediated currents in rat suprachiasmatic neurons.
  Strecker GJ, Park WK, Dudek FE. Strecker GJ, et al. J Neurophysiol. 1999 Jan;81(1):184-91. doi: 10.1152/jn.1999.81.1.184. J Neurophysiol. 1999. PMID: 9914279
• Heterogeneity of GABAA-receptors: cell-specific expression, pharmacology, and regulation.
  Mohler H, Knoflach F, Paysan J, Motejlek K, Benke D, Lüscher B, Fritschy JM. Mohler H, et al. Neurochem Res. 1995 May;20(5):631-6. doi: 10.1007/BF01694546. Neurochem Res. 1995. PMID: 7643969 Review.

Cited by

• Zolpidem is a potent stoichiometry-selective modulator of α1β3 GABAA receptors: evidence of a novel benzodiazepine site in the α1-α1 interface.
  Che Has AT, Absalom N, van Nieuwenhuijzen PS, Clarkson AN, Ahring PK, Chebib M. Che Has AT, et al. Sci Rep. 2016 Jun 27;6:28674. doi: 10.1038/srep28674. Sci Rep. 2016. PMID: 27346730 Free PMC article.
• Tyrosine phosphorylation of GABAA receptor γ2-subunit regulates tonic and phasic inhibition in the thalamus.
  Nani F, Bright DP, Revilla-Sanchez R, Tretter V, Moss SJ, Smart TG. Nani F, et al. J Neurosci. 2013 Jul 31;33(31):12718-27. doi: 10.1523/JNEUROSCI.0388-13.2013. J Neurosci. 2013. PMID: 23904608 Free PMC article.
• Identification of an inhibitory Zn2+ binding site on the human glycine receptor alpha1 subunit.
  Harvey RJ, Thomas P, James CH, Wilderspin A, Smart TG. Harvey RJ, et al. J Physiol. 1999 Oct 1;520 Pt 1(Pt 1):53-64. doi: 10.1111/j.1469-7793.1999.00053.x. J Physiol. 1999. PMID: 10517800 Free PMC article.
• Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.
  Bowser DN, Wagner DA, Czajkowski C, Cromer BA, Parker MW, Wallace RH, Harkin LA, Mulley JC, Marini C, Berkovic SF, Williams DA, Jones MV, Petrou S. Bowser DN, et al. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15170-5. doi: 10.1073/pnas.212320199. Epub 2002 Nov 1. Proc Natl Acad Sci U S A. 2002. PMID: 12415111 Free PMC article.
• Synaptic Zinc Enhances Inhibition Mediated by Somatostatin, but not Parvalbumin, Cells in Mouse Auditory Cortex.
  Kouvaros S, Kumar M, Tzounopoulos T. Kouvaros S, et al. Cereb Cortex. 2020 Jun 1;30(7):3895-3909. doi: 10.1093/cercor/bhaa005. Cereb Cortex. 2020. PMID: 32090251 Free PMC article.

References

1. 1. Brain Res Mol Brain Res. 1990 Aug;8(3):199-208 - PubMed
2. 1. Neuron. 1990 Dec;5(6):781-8 - PubMed
3. 1. J Neurochem. 1991 Feb;56(2):713-5 - PubMed
4. 1. J Pharm Pharmacol. 1990 Jun;42(6):377-87 - PubMed
5. 1. Eur J Pharmacol. 1990 Jul 31;189(1):77-88 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • PubMed Central
  • Wiley