The therapeutic potential of monoamine oxidase inhibitors - PubMed (original) (raw)
Review
doi: 10.1038/nrn1883.
Affiliations
- PMID: 16552415
- DOI: 10.1038/nrn1883
Review
The therapeutic potential of monoamine oxidase inhibitors
Moussa B H Youdim et al. Nat Rev Neurosci. 2006 Apr.
Abstract
Monoamine oxidase inhibitors were among the first antidepressants to be discovered and have long been used as such. It now seems that many of these agents might have therapeutic value in several common neurodegenerative conditions, independently of their inhibition of monoamine oxidase activity. However, many claims and some counter-claims have been made about the physiological importance of these enzymes and the potential of their inhibitors. We evaluate these arguments in the light of what we know, and still have to learn, of the structure, function and genetics of the monoamine oxidases and the disparate actions of their inhibitors.
Similar articles
- Kinetic behavior and reversible inhibition of monoamine oxidases--enzymes that many want dead.
Tipton KF, Davey GP, McDonald AG. Tipton KF, et al. Int Rev Neurobiol. 2011;100:43-64. doi: 10.1016/B978-0-12-386467-3.00003-0. Int Rev Neurobiol. 2011. PMID: 21971002 Review. - Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases.
Rahman T, Rahmatullah M. Rahman T, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):537-40. doi: 10.1016/j.bmcl.2009.11.106. Epub 2009 Nov 26. Bioorg Med Chem Lett. 2010. PMID: 19969454 - Inhibition of monoamine oxidase B by N-methyl-2-phenylmaleimides.
Manley-King CI, Terre'Blanche G, Castagnoli N Jr, Bergh JJ, Petzer JP. Manley-King CI, et al. Bioorg Med Chem. 2009 Apr 15;17(8):3104-10. doi: 10.1016/j.bmc.2009.03.005. Epub 2009 Mar 9. Bioorg Med Chem. 2009. PMID: 19324554 - Plant secondary metabolites- potent inhibitors of monoamine oxidase isoforms.
Mathew B, Suresh J, Mathew GE, Parasuraman R, Abdulla N. Mathew B, et al. Cent Nerv Syst Agents Med Chem. 2014;14(1):28-33. doi: 10.2174/1871524914666140826111930. Cent Nerv Syst Agents Med Chem. 2014. PMID: 25142815 Review. - Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
La Regina G, Silvestri R, Gatti V, Lavecchia A, Novellino E, Befani O, Turini P, Agostinelli E. La Regina G, et al. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. doi: 10.1016/j.bmc.2008.09.072. Epub 2008 Oct 2. Bioorg Med Chem. 2008. PMID: 18951803
Cited by
- Effects of Natural Monoamine Oxidase Inhibitors on Anxiety-Like Behavior in Zebrafish.
Jaka O, Iturria I, van der Toorn M, Hurtado de Mendoza J, Latino DARS, Alzualde A, Peitsch MC, Hoeng J, Koshibu K. Jaka O, et al. Front Pharmacol. 2021 May 13;12:669370. doi: 10.3389/fphar.2021.669370. eCollection 2021. Front Pharmacol. 2021. PMID: 34079463 Free PMC article. - Inhibition of MAO-A and stimulation of behavioural activities in mice by the inactive prodrug form of the anti-influenza agent oseltamivir.
Hiasa M, Isoda Y, Kishimoto Y, Saitoh K, Kimura Y, Kanai M, Shibasaki M, Hatakeyama D, Kirino Y, Kuzuhara T. Hiasa M, et al. Br J Pharmacol. 2013 May;169(1):115-29. doi: 10.1111/bph.12102. Br J Pharmacol. 2013. PMID: 23320399 Free PMC article. - Histological effects of long term consumption of nutmeg on the medial geniculate body of adult Wistar rats.
Adjene JO, Nwose EU. Adjene JO, et al. N Am J Med Sci. 2010 Mar;2(3):134-7. doi: 10.4297/najms.2010.3134. N Am J Med Sci. 2010. PMID: 22624127 Free PMC article. - Inhibition of Butyrylcholinesterase and Human Monoamine Oxidase-B by the Coumarin Glycyrol and Liquiritigenin Isolated from Glycyrrhiza uralensis.
Jeong GS, Kang MG, Lee JY, Lee SR, Park D, Cho M, Kim H. Jeong GS, et al. Molecules. 2020 Aug 26;25(17):3896. doi: 10.3390/molecules25173896. Molecules. 2020. PMID: 32859055 Free PMC article. - Monoamine Oxidase Inhibitors: A Review of Their Anti-Inflammatory Therapeutic Potential and Mechanisms of Action.
Ostadkarampour M, Putnins EE. Ostadkarampour M, et al. Front Pharmacol. 2021 Apr 30;12:676239. doi: 10.3389/fphar.2021.676239. eCollection 2021. Front Pharmacol. 2021. PMID: 33995107 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical