[Biochips--tools of 21st century medicine] - PubMed (original) (raw)
[Article in German]
Affiliations
- PMID: 16553220
[Biochips--tools of 21st century medicine]
[Article in German]
J Bürger. Versicherungsmedizin. 2006.
Abstract
In the next years biochips will enter into clinical medicine. Each larger diagnostics laboratory will offer genetic tests with this method. In this article the potential of biochips is shown by two examples: Differentiation and prognosis in breast cancer and individualized drug therapy (pharmacogenetics). In cancer the gene expression profile permits an accuracy of differentiation and prognosis that was impossible so far. Already soon oncologists will make their therapeutic decisions on the basis of biochip-based gene expression profiles. For an individualized drug therapy extensive genetic tests must be accomplished, above all of the cytochrome P450 system. An already available biochip seems to make this possible reliably and economically. Moreover, in science biochips will play a substantial role in the analysis of the genetic basis of common diseases. If these diseases are understood once, the clinical use of biochips will open an enormous potential for a predictive medicine. Biochips are a relevant topic for insurers--partially already today, much more however in the future.
Similar articles
- Applications of biochips: from diagnostics to personalized medicine.
Jain KK. Jain KK. Curr Opin Drug Discov Devel. 2004 May;7(3):285-9. Curr Opin Drug Discov Devel. 2004. PMID: 15216931 Review. - Role of Proteomics in the Development of Personalized Medicine.
Jain KK. Jain KK. Adv Protein Chem Struct Biol. 2016;102:41-52. doi: 10.1016/bs.apcsb.2015.09.002. Epub 2015 Nov 11. Adv Protein Chem Struct Biol. 2016. PMID: 26827601 Review. - Personalized oncology: recent advances and future challenges.
Kalia M. Kalia M. Metabolism. 2013 Jan;62 Suppl 1:S11-4. doi: 10.1016/j.metabol.2012.08.016. Epub 2012 Sep 19. Metabolism. 2013. PMID: 22999010 Review. - Prenatal genetic care: debates and considerations of the past, present and future.
Faas BH. Faas BH. Expert Opin Biol Ther. 2015;15(8):1101-5. doi: 10.1517/14712598.2015.1045873. Epub 2015 May 10. Expert Opin Biol Ther. 2015. PMID: 25959656 Review. - The current status and future potential of personalized diagnostics: Streamlining a customized process.
Richmond TD. Richmond TD. Biotechnol Annu Rev. 2008;14:411-22. doi: 10.1016/S1387-2656(08)00015-X. Biotechnol Annu Rev. 2008. PMID: 18606372 Review.
Cited by
- Overexpression of S100B, TM4SF4, and OLFM4 genes is correlated with liver metastasis in Taiwanese colorectal cancer patients.
Huang MY, Wang HM, Chang HJ, Hsiao CP, Wang JY, Lin SR. Huang MY, et al. DNA Cell Biol. 2012 Jan;31(1):43-9. doi: 10.1089/dna.2011.1264. Epub 2011 Oct 19. DNA Cell Biol. 2012. PMID: 22011044 Free PMC article. - Development of a Pharmacogenetic Lab-on-Chip Assay Based on the In-Check Technology to Screen for Genetic Variations Associated to Adverse Drug Reactions to Common Chemotherapeutic Agents.
Iemmolo R, La Cognata V, Morello G, Guarnaccia M, Arbitrio M, Alessi E, Cavallaro S. Iemmolo R, et al. Biosensors (Basel). 2020 Dec 9;10(12):202. doi: 10.3390/bios10120202. Biosensors (Basel). 2020. PMID: 33317085 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Medical