Bacteria and cancer: cause, coincidence or cure? A review - PubMed (original) (raw)

Bacteria and cancer: cause, coincidence or cure? A review

D L Mager. J Transl Med. 2006.

Abstract

Research has found that certain bacteria are associated with human cancers. Their role, however, is still unclear. Convincing evidence links some species to carcinogenesis while others appear promising in the diagnosis, prevention or treatment of cancers. The complex relationship between bacteria and humans is demonstrated by Helicobacter pylori and Salmonella typhi infections. Research has shown that H. pylori can cause gastric cancer or MALT lymphoma in some individuals. In contrast, exposure to H. pylori appears to reduce the risk of esophageal cancer in others. Salmonella typhi infection has been associated with the development of gallbladder cancer; however S. typhi is a promising carrier of therapeutic agents for melanoma, colon and bladder cancers. Thus bacterial species and their roles in particular cancers appear to differ among different individuals. Many species, however, share an important characteristic: highly site-specific colonization. This critical factor may lead to the development of non-invasive diagnostic tests, innovative treatments and cancer vaccines.

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References

1. 1. Pisani P, Parkin DM, Munoz N, Ferlay J. Cancer and infection: estimates of the attributable fraction in 1990. Cancer Epidemiol Biomarkers Prev. 1997;6:387–400. - PubMed
2. 1. Pujol FH, Devesa M. Genotypic variability of hepatitis viruses associated with chronic infection and the development of hepatocellular carcinoma. J Clin Gastroenterol. 2005;39:611–618. doi: 10.1097/01.mcg.0000170770.49394.92. - DOI - PubMed
3. 1. Ord RA, Blanchaert RH., Jr Current management of oral cancer. A multidisciplinary approach. J Am Dent Assoc. 2001;132:19S–23S. - PubMed
4. 1. Crowe SE. Helicobacter infection, chronic inflammation, and the development of malignancy. Curr Opin Gastroenterol. 2005;1:32–8. - PubMed
5. 1. Montalban C, Santon A, Boixeda D, Bellas C. Regression of gastric high grade mucosa associated lymphoid tissue (MALT) lymphoma after Helicobacter pylori eradication. Gut. 2001;49:584–587. doi: 10.1136/gut.49.4.584. - DOI - PMC - PubMed

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