Plasmodium falciparum in vitro susceptibility to antimalarial drugs in Casamance (southwestern Senegal) during the first 5 years of routine use of artesunate-amodiaquine - PubMed (original) (raw)

Plasmodium falciparum in vitro susceptibility to antimalarial drugs in Casamance (southwestern Senegal) during the first 5 years of routine use of artesunate-amodiaquine

P Agnamey et al. Antimicrob Agents Chemother. 2006 Apr.

Abstract

We have monitored the in vitro sensitivities of Plasmodium falciparum isolates predeployment and during the deployment of artesunate plus amodiaquine treatment in Mlomp, Casamance (southwestern Senegal) during 2000 to 2004. Parasites remained susceptible to both drugs. Chloroquine resistance levels were high but stable. Quinine continues to be effective.

PubMed Disclaimer

Figures

FIG. 1.

Box plots of log-transformed IC50s (in nM) for chloroquine (a), quinine (b), monodesethyl amodiaquine (c), and artemisinin (d) by year (1997 and 2000 to 2004). The percentages of isolates above the cutoff value for in vitro resistance (dotted horizontal lines) are displayed for each drug. The top (or the base) of the whisker corresponds to the largest (or the lowest) observed value within the 1.5× interquartile range (IQ) from the 75th (or 25th) percentile. □, mean; ⋄, values outside 1.5× IQ.

Cited by

Plasmodium falciparum susceptibility to anti-malarial drugs in Dakar, Senegal, in 2010: an ex vivo and drug resistance molecular markers study.
Fall B, Pascual A, Sarr FD, Wurtz N, Richard V, Baret E, Diémé Y, Briolant S, Bercion R, Wade B, Tall A, Pradines B. Fall B, et al. Malar J. 2013 Mar 20;12:107. doi: 10.1186/1475-2875-12-107. Malar J. 2013. PMID: 23510258 Free PMC article.
Trends in malaria morbidity following the introduction of artesunate plus amodiaquine combination in M'lomp village dispensary, south-western Senegal.
Sarrassat S, Senghor P, Le Hesran JY. Sarrassat S, et al. Malar J. 2008 Oct 24;7:215. doi: 10.1186/1475-2875-7-215. Malar J. 2008. PMID: 18950485 Free PMC article.
Geometric least squares means ratios for the analysis of Plasmodium falciparum in vitro susceptibility to antimalarial drugs.
Vaillant M, Olliaro P. Vaillant M, et al. Malar J. 2007 Nov 26;6:156. doi: 10.1186/1475-2875-6-156. Malar J. 2007. PMID: 18039388 Free PMC article.
Ex vivo susceptibility of Plasmodium falciparum isolates from Dakar, Senegal, to seven standard anti-malarial drugs.
Fall B, Diawara S, Sow K, Baret E, Diatta B, Fall KB, Mbaye PS, Fall F, Diémé Y, Rogier C, Wade B, Bercion R, Pradines B. Fall B, et al. Malar J. 2011 Oct 20;10:310. doi: 10.1186/1475-2875-10-310. Malar J. 2011. PMID: 22014157 Free PMC article.
Understanding human-Plasmodium falciparum immune interactions uncovers the immunological role of worms.
Roussilhon C, Brasseur P, Agnamey P, Pérignon JL, Druilhe P. Roussilhon C, et al. PLoS One. 2010 Feb 19;5(2):e9309. doi: 10.1371/journal.pone.0009309. PLoS One. 2010. PMID: 20174576 Free PMC article.

References

1. Adjuik, M., P. Agnamey, A. Babiker, S. Borrmann, P. Brasseur, F. Cobelens, S. Diallo, J. F. Faucher, P. Garner, S. Gikunda, P. G. Kremsner, S. Krishna, B. Lell, M. Loolpapit, P. B. Matsiegui, M. A. Missinou, J. Mwanza, F. Ntoumi, P. Olliaro, P. Osimbo, P. Rezbach, M. Cisse, E. Some, and W. R. J. Taylor. 2002. Artesunate-amodiaquine versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial. Lancet 359:1365-1372. - PubMed
1. Agnamey, P., P. Brasseur, M. Cissé, O. Gaye, J. Dumoulin, J. Rigal, W. R. J. Taylor, and P. Olliaro. 2005. Economic evaluation of a policy change from single-agent treatment for suspected malaria to artesunate-amodiaquine for microscopically confirmed uncomplicated falciparum malaria in the Oussouye district of southwestern Senegal. Trop. Med. Int. Health 10:926-933. - PubMed
1. Brasseur, P., P. Druilhe, J. Kouamouo, O. Brandicourt, M. Danis, and S. R. Moyou. 1986. High level of sensitivity to choloroquine of 72 Plasmodium falciparum isolates from southern Cameroon in January 1985. Am. J. Trop. Med. Hyg. 35:711-716. - PubMed
1. Brasseur, P., R. Guiguemde, S. Diallo, V. Guiyedi, M. Kombila, P. Ringwald, and P. Olliaro. 1999. Amodiaquine remains effective for treating uncomplicated malaria in West and Central Africa. Trans. R. Soc. Trop. Med. Hyg. 86:609-612. - PubMed
1. Churchill, F. C., L. C. Patchen, C. C. Campbell, I. K. Schwartz, P. Nguyen-Dinh, and C. M. Dickinson. 1985. Amodiaquine as pro-drug: the importance of metabolite(s) in the antimalarial effect of amodiaquine in humans. Life Sci. 36:53-62. - PubMed

Plasmodium falciparum in vitro susceptibility to antimalarial drugs in Casamance (southwestern Senegal) during the first 5 years of routine use of artesunate-amodiaquine - PubMed (original) (raw)