The molecular biology of eosinophil granule proteins - PubMed (original) (raw)
Review
The molecular biology of eosinophil granule proteins
K J Hamann et al. Int Arch Allergy Appl Immunol. 1991.
Abstract
Here, we briefly review the molecular biology of the human eosinophil granule proteins, major basic protein (MBP), eosinophil peroxidase (EPO), eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN). The nucleotide sequence of MBP cDNA indicates that MBP is translated as a 25.2-kilodalton preproprotein; the mpb gene consists of 6 exons and 5 introns spanning 3.3 kilobases (kb). The approximately 2.1-kb nucleotide sequence of EPO cDNA corresponds to a prosequence, light chain and heavy chain in that order; similarities to other peroxidases suggest the existence of a multigene family. EDN and ECP cDNAs and genes are remarkably similar throughout, suggesting a relatively recent divergence. Promoter regions of the 4 genes show interesting differences and similarities which may be related to differential gene regulation.
Similar articles
- [Biochemistry and biological activities of eosinophil granule proteins].
Enokihara H, Koike T. Enokihara H, et al. Nihon Rinsho. 1993 Mar;51(3):605-12. Nihon Rinsho. 1993. PMID: 7684096 Review. Japanese. - Decreased expression of eosinophil peroxidase and major basic protein messenger RNAs during eosinophil maturation.
Gruart V, Truong MJ, Plumas J, Zandecki M, Kusnierz JP, Prin L, Vinatier D, Capron A, Capron M. Gruart V, et al. Blood. 1992 May 15;79(10):2592-7. Blood. 1992. PMID: 1375105 - Eosinophil granule proteins in peripheral blood granulocytes.
Abu-Ghazaleh RI, Dunnette SL, Loegering DA, Checkel JL, Kita H, Thomas LL, Gleich GJ. Abu-Ghazaleh RI, et al. J Leukoc Biol. 1992 Dec;52(6):611-8. doi: 10.1002/jlb.52.6.611. J Leukoc Biol. 1992. PMID: 1464733 - Eosinophil major basic protein induces degranulation and IL-8 production by human eosinophils.
Kita H, Abu-Ghazaleh RI, Sur S, Gleich GJ. Kita H, et al. J Immunol. 1995 May 1;154(9):4749-58. J Immunol. 1995. PMID: 7722326 - [Eosinophil granule proteins (MBP, ECP, EPX/EDN, EPO)--a possible process of eosinophil activation and degranulation].
Tsuda S, Miyasato M. Tsuda S, et al. Nihon Rinsho. 1993 Mar;51(3):613-9. Nihon Rinsho. 1993. PMID: 8492433 Review. Japanese.
Cited by
- Origins and functions of eosinophils in two non-mucosal tissues.
Day KS, Rempel L, Rossi FMV, Theret M. Day KS, et al. Front Immunol. 2024 Mar 22;15:1368142. doi: 10.3389/fimmu.2024.1368142. eCollection 2024. Front Immunol. 2024. PMID: 38585275 Free PMC article. Review. - Upper airway disease diagnosis as a predictive biomarker of therapeutic response to biologics in severe asthma.
Cottin S, Doyen V, Pilette C. Cottin S, et al. Front Med (Lausanne). 2023 Mar 22;10:1129300. doi: 10.3389/fmed.2023.1129300. eCollection 2023. Front Med (Lausanne). 2023. PMID: 37035303 Free PMC article. Review. - Proposed refined diagnostic criteria and classification of eosinophil disorders and related syndromes.
Valent P, Klion AD, Roufosse F, Simon D, Metzgeroth G, Leiferman KM, Schwaab J, Butterfield JH, Sperr WR, Sotlar K, Vandenberghe P, Hoermann G, Haferlach T, Moriggl R, George TI, Akin C, Bochner BS, Gotlib J, Reiter A, Horny HP, Arock M, Simon HU, Gleich GJ. Valent P, et al. Allergy. 2023 Jan;78(1):47-59. doi: 10.1111/all.15544. Epub 2022 Oct 19. Allergy. 2023. PMID: 36207764 Free PMC article. Review. - Blood Eosinophils Are Associated with Efficacy of Targeted Therapy in Patients with Advanced Melanoma.
Wendlinger S, Wohlfarth J, Kreft S, Siedel C, Kilian T, Dischinger U, Heppt MV, Wistuba-Hamprecht K, Meier F, Goebeler M, Schadendorf D, Gesierich A, Kosnopfel C, Schilling B. Wendlinger S, et al. Cancers (Basel). 2022 May 4;14(9):2294. doi: 10.3390/cancers14092294. Cancers (Basel). 2022. PMID: 35565423 Free PMC article. - Serum Proteomic Profile of Asthmatic Patients after Six Months of Benralizumab and Mepolizumab Treatment.
Vantaggiato L, Cameli P, Bergantini L, d'Alessandro M, Shaba E, Carleo A, Di Giuseppe F, Angelucci S, Sebastiani G, Dotta F, Bini L, Bargagli E, Landi C. Vantaggiato L, et al. Biomedicines. 2022 Mar 24;10(4):761. doi: 10.3390/biomedicines10040761. Biomedicines. 2022. PMID: 35453511 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Research Materials
Miscellaneous