Selective serotonin reuptake inhibitors and adverse pregnancy outcomes - PubMed (original) (raw)
Selective serotonin reuptake inhibitors and adverse pregnancy outcomes
Shi Wu Wen et al. Am J Obstet Gynecol. 2006 Apr.
Abstract
Objective: The purpose of this study was to assess the safety of the use of selective serotonin reuptake inhibitors in pregnancy.
Study design: We carried out a retrospective cohort study of 972 pregnant women who had been given at least 1 selective serotonin reuptake inhibitor prescription in the year before delivery and 3878 pregnant women who did not receive selective serotonin reuptake inhibitors and who were matched by the year of the infant's birth, the type of institute at birth, and the mother's postal code from 1990 to 2000 in the Canadian province of Saskatchewan.
Results: The risks of low birth weight (adjusted odds ratio, 1.58; 95% CI, 1.19, 2.11), preterm birth (adjusted odds ratio, 1.57; 95% CI, 1.28, 1.92), fetal death (adjusted odds ratio, 2.23; 95% CI, 1.01, 4.93), and seizures (adjusted odds ratio, 3.87; 95% CI, 1.00, 14.99) were increased in infants who were born to mothers who had received selective serotonin reuptake inhibitor therapy.
Conclusion: The use of selective serotonin reuptake inhibitors in pregnancy may increase the risks of low birth weight, preterm birth, fetal death, and seizures.
Comment in
- Adverse pregnancy outcomes with SSRIs.
Goldstein DJ. Goldstein DJ. Am J Obstet Gynecol. 2007 Jan;196(1):e25; author reply e25. doi: 10.1016/j.ajog.2006.06.027. Epub 2006 Jul 5. Am J Obstet Gynecol. 2007. PMID: 16824467 No abstract available. - SSRIs and adverse pregnancy outcomes.
Heres M, Honig A, Wennink H. Heres M, et al. Am J Obstet Gynecol. 2007 Jan;196(1):e26; author reply e26. doi: 10.1016/j.ajog.2006.06.025. Epub 2006 Jul 17. Am J Obstet Gynecol. 2007. PMID: 16846578 No abstract available.
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