Psychological assessment of the effects of treatment with phytoestrogens on postmenopausal women: a randomized, double-blind, crossover, placebo-controlled study - PubMed (original) (raw)
Randomized Controlled Trial
Psychological assessment of the effects of treatment with phytoestrogens on postmenopausal women: a randomized, double-blind, crossover, placebo-controlled study
Maria Luisa Casini et al. Fertil Steril. 2006 Apr.
Free article
Retraction in
Abstract
Objective: To investigate the effects of soy isoflavones on mood and cognitive function in postmenopausal women.
Design: Randomized, double-blind, cross-over, placebo-controlled trial.
Setting: University Hospital, Milan, Italy; A.G.UN.CO. Obstetrics and Gynaecology Centre, Rome, Italy.
Patient(s): Seventy-eight postmenopausal women.
Intervention(s): We administered 60 mg/day isoflavones or placebo for 6 months. After a washout period of 1 month, the patients who had been treated with phytoestrogens received placebo, and those who previously received placebo were administered phytoestrogens (for 6 months).
Main outcome measure(s): Cognitive performance and mood were assessed by a battery of tests at the end of each treatment period. At the end of the study, the patients were also asked whether they preferred the first or second treatment.
Result(s): The 17 scores on cognitive performance test and the 6 for mood assessments 6 showed an advantage for the treatment with phytoestrogens. Similarly, of the 8 visual analogue scales used to indicate mood, 7 improved significantly after the treatment with phytoestrogens. Moreover, 49 patients preferred phytoestrogens, 9 placebo, and 18 had no preference. The preference was not related to the order of treatment.
Conclusion(s): These results suggest that isoflavones may have positive effects on postmenopausal women improving cognitive performance and mood.
Similar articles
- Falls prevention interventions for community-dwelling older adults: systematic review and meta-analysis of benefits, harms, and patient values and preferences.
Pillay J, Gaudet LA, Saba S, Vandermeer B, Ashiq AR, Wingert A, Hartling L. Pillay J, et al. Syst Rev. 2024 Nov 26;13(1):289. doi: 10.1186/s13643-024-02681-3. Syst Rev. 2024. PMID: 39593159 Free PMC article. - Safety, tolerability, and efficacy outcomes of the Investigation of Levetiracetam in Alzheimer's disease (ILiAD) study: a pilot, double-blind placebo-controlled crossover trial.
Sen A, Toniolo S, Tai XY, Akinola M, Symmonds M, Mura S, Galloway J, Hallam A, Chan JYC, Koychev I, Butler C, Geddes J, Jones GD, Tabi Y, Maio R, Frangou E, Love S, Thompson S, Van Der Putt R, Manohar SG, McShane R, Husain M. Sen A, et al. Epilepsia Open. 2024 Dec;9(6):2353-2364. doi: 10.1002/epi4.13070. Epub 2024 Oct 14. Epilepsia Open. 2024. PMID: 39400461 Free PMC article. Clinical Trial. - Antioxidants for female subfertility.
Showell MG, Mackenzie-Proctor R, Jordan V, Hart RJ. Showell MG, et al. Cochrane Database Syst Rev. 2020 Aug 27;8(8):CD007807. doi: 10.1002/14651858.CD007807.pub4. Cochrane Database Syst Rev. 2020. PMID: 32851663 Free PMC article. - Oral budesonide for induction of remission in ulcerative colitis.
Sherlock ME, MacDonald JK, Griffiths AM, Steinhart AH, Seow CH. Sherlock ME, et al. Cochrane Database Syst Rev. 2015 Oct 26;2015(10):CD007698. doi: 10.1002/14651858.CD007698.pub3. Cochrane Database Syst Rev. 2015. PMID: 26497719 Free PMC article. Review. - Oxycodone for neuropathic pain and fibromyalgia in adults.
Gaskell H, Moore RA, Derry S, Stannard C. Gaskell H, et al. Cochrane Database Syst Rev. 2014 Jun 23;(6):CD010692. doi: 10.1002/14651858.CD010692.pub2. Cochrane Database Syst Rev. 2014. PMID: 24956205 Updated. Review.
Cited by
- Herbal extracts and phytochemicals: plant secondary metabolites and the enhancement of human brain function.
Kennedy DO, Wightman EL. Kennedy DO, et al. Adv Nutr. 2011 Jan;2(1):32-50. doi: 10.3945/an.110.000117. Epub 2011 Jan 10. Adv Nutr. 2011. PMID: 22211188 Free PMC article. Review. - The effects of soy extract on spatial learning and memory damage induced by global ischemia in ovariectomised rats.
Vafaee F, Hosseini M, Sadeghinia HR, Hadjzadeh MA, Soukhtanloo M, Rahimi M. Vafaee F, et al. Malays J Med Sci. 2014 May;21(3):19-30. Malays J Med Sci. 2014. PMID: 25246832 Free PMC article. - Dietary phytoestrogen intakes and cognitive function during the menopausal transition: results from the Study of Women's Health Across the Nation Phytoestrogen Study.
Greendale GA, Huang MH, Leung K, Crawford SL, Gold EB, Wight R, Waetjen E, Karlamangla AS. Greendale GA, et al. Menopause. 2012 Aug;19(8):894-903. doi: 10.1097/gme.0b013e318242a654. Menopause. 2012. PMID: 22415567 Free PMC article. - Effects of botanical dietary supplements on cardiovascular, cognitive, and metabolic function in males and females.
Carlson S, Peng N, Prasain JK, Wyss JM. Carlson S, et al. Gend Med. 2008;5 Suppl A(Suppl A):S76-90. doi: 10.1016/j.genm.2008.03.008. Gend Med. 2008. PMID: 18395685 Free PMC article. Review. - Effects of botanicals and combined hormone therapy on cognition in postmenopausal women.
Maki PM, Rubin LH, Fornelli D, Drogos L, Banuvar S, Shulman LP, Geller SE. Maki PM, et al. Menopause. 2009 Nov-Dec;16(6):1167-77. doi: 10.1097/gme.0b013e3181ace484. Menopause. 2009. PMID: 19590458 Free PMC article. Clinical Trial.